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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aromatic Polyketides and Macrolides from Microsphaeropsis arundinis

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Author(s):
Botero, Weslei Bruno [1] ; de Amorim, Marcelo R. [1] ; Carlos, Iracilda Z. [2] ; Polesi, Marisa C. [2] ; dos Santos, Lourdes C. [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Paulista Unesp, Dept Quim Organ, Inst Quim, BR-14800060 Araraquara, SP - Brazil
[2] Univ Estadual Paulista Unesp, Escola Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 31, n. 2, p. 364-369, FEB 2020.
Web of Science Citations: 0
Abstract

The endophytic fungus Microsphaeropsis arundinis was isolated from the capitula of the tropical plant Paepalanthus planifolius (Eriocaulaceae). The fungus was cultivated in seven different media, and the ethyl acetate extracts were tested against tumor cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay. The culture was scaled up using parboiled rice medium, and the crude extract was purified by classical chromatographic analyses, leading to the isolation of seven compounds. The seven compounds isolated from the culture media included a new aromatic polyketide (1) and other known metabolites. The structures of all the compounds were elucidated by 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS) analyses. An evaluation of the cytotoxicity of all the isolated compounds showed that these compounds exhibit less activity in comparison with the extract cultured in parboiled rice. (AU)

FAPESP's process: 15/04899-3 - Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity
Grantee:Lourdes Campaner dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 15/11058-5 - Chemical and biological prospecting of endophytic fungi associated with Paepalanthus planifolius (Eriocaulaceae)
Grantee:Marcelo Rodrigues de Amorim
Support Opportunities: Scholarships in Brazil - Doctorate