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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mucoadhesive films based on gellan gum/pectin blends as potential platform for buccal drug delivery

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Prezotti, Fabiola Garavello [1] ; Siedle, Izabel [2] ; Boni, Fernanda Isadora [1] ; Chorilli, Marlus [1] ; Mueller, Ingrid [2] ; Ferreira Cury, Beatriz Stringhetti [1]
Total Authors: 6
[1] Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, UNESP, Araraquara, SP - Brazil
[2] Univ Albstadt Sigmaringen, Fac Pharmaceut Engn, Sigmaringen - Germany
Total Affiliations: 2
Document type: Journal article
Source: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY; v. 25, n. 2, p. 159-167, FEB 7 2020.
Web of Science Citations: 0

Films of gellan gum:pectin blends were prepared by solvent casting method. Gellan gum:pectin mass ratios were varied (4:1; 1:1; 1:4) at different concentrations (3% or 4%) and glycerol was used as plasticizer (1 or 2%). The films were thin (18-30 mu m), translucent, flexible, and homogeneous. The surface pH was suitable for buccal application. All films reached high mechanical resistance and the mucoadhesive ability of them was evidenced. High ratio of gellan gum improved the mechanical resistance and the mucoadhesion of the films as well as the control of drug release rates. The films did not disintegrate in simulate saliva up to 24 h and curcumin release could be sustained up to 12 h. The set of data evidence that the films designed in this work represent a potential platform for buccal drug delivery. (AU)

FAPESP's process: 11/16847-7 - Gellan-pectin microcapsules as a potential strategy for colon-specific drug delivery.
Grantee:Fabíola Garavello Prezotti
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
Grantee:Maria Vitória Lopes Badra Bentley
Support Opportunities: Research Projects - Thematic Grants