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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The impact of arginase activity on virulence factors of Leishmania amazonensis

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Author(s):
Aoki, Juliana Ide [1] ; Laranjeira-Silva, Maria Fernanda [1] ; Muxel, Sandra Marcia [1] ; Floeter-Winter, Lucile Maria [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biosci, Dept Physiol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Current Opinion in Microbiology; v. 52, p. 110-115, DEC 2019.
Web of Science Citations: 0
Abstract

The outcome of Leishmania infection depends on the parasite species arid the host immune response. Virulence factors have been extensively studied over the years in an effort to find efficient vaccines and/or treatments for Leishmania infection. Arginase activity in Leishmania has been described as an essential player for the polyamines pathway, impacting parasite replication and infectivity. Considering previous studies showing that the absence of arginase activity leads to low infectivity of Leishmania amazonensis, we reanalyzed transcriptomic data comparing both promastigotes and axenic amastigotes from L. amazonensis wild type (La-WT) and L. amazonensis arginase knockout (La-arg) backgrounds. The analysis produced a new compilation of modulated transcripts that indicated the role of arginase not only in the polyamines pathway but also in the modulation of virulence factors involved in parasite recognition, growth and differentiation. (AU)

FAPESP's process: 17/23933-3 - Identification and characterization of membrane proteins involved in iron transport and metabolism in Leishmania
Grantee:Maria Fernanda Laranjeira da Silva
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 14/50717-1 - Biochemical, physiological and functional genomic studies of Leishmania-macrophage interaction
Grantee:Lucile Maria Floeter-Winter
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/03273-6 - Dual transcriptome profiling of murine macrophages infected with Leishmania amazonensis
Grantee:Juliana Ide Aoki
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/19815-2 - Role of miRNAs in the TLRs-mediated immune response to Leishmania amazonensis infection
Grantee:Sandra Marcia Muxel
Support Opportunities: Regular Research Grants