Biochemical, physiological and functional genomic studies of Leishmania-macrophage interaction

• Grant number: 14/50717-1
• Support type: Research Projects - Thematic Grants
• Duration: June 01, 2015 - May 31, 2019
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal researcher: Lucile Maria Floeter-Winter
• Grantee: Lucile Maria Floeter-Winter
• Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The biology of parasites belonging to Leishmania genus offers unique features as model for studying the host - pathogen interaction. Here we propose three sub-projects to study biochemical and physiological aspects of this interaction, primarily upon infe (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ACUNA, STEPHANIE MAIA; ZANATTA, JONATHAN MIGUEL; DE ALMEIDA BENTO, CAMILLA; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. iR-294 and miR-410 Negatively Regulate Tnfa, Arginine Transporter Cat1/2, and Nos2 mRNAs in Murine Macrophages Infected with Leishmania amazonensi. ON-CODING RN, v. 8, n. 1 FEB 2022. Web of Science Citations: 0.

AOKI, JULIANA IDE; LARANJEIRA-SILVA, MARIA FERNANDA; MUXEL, SANDRA MARCIA; FLOETER-WINTER, LUCILE MARIA. The impact of arginase activity on virulence factors of Leishmania amazonensis. Current Opinion in Microbiology, v. 52, p. 110-115, DEC 2019. Web of Science Citations: 0.

RIBEIRO FERNANDES, JULIANE CRISTINA; AOKI, JULIANA IDE; ACUNA, STEPHANIE MAIA; ZAMPIERI, RICARDO ANDRADE; MARKUS, REGINA P.; FLOETER-WINTER, LUCILE MARIA; MUXEL, SANDRA MARCIA. Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 9, MAR 20 2019. Web of Science Citations: 2.

MUXEL, SANDRA MARCIA; ACUNA, STEPHANIE MAIA; AOKI, JULIANA IDE; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA. Toll-Like Receptor and miRNA-let-7e Expression Alter the Inflammatory Response in Leishmania amazonensis-Infected Macrophages. FRONTIERS IN IMMUNOLOGY, v. 9, NOV 29 2018. Web of Science Citations: 3.

MUXEL, SANDRA M.; AOKI, JULIANA I.; FERNANDES, JULIANE C. R.; LARANJEIRA-SILVA, MARIA F.; ZAMPIERI, RICARDO A.; ACUNA, STEPHANIE M.; MULLER, KARL E.; VANDERLINDE, RUBIA H.; FLOETER-WINTER, LUCILE M. Arginine and Polyamines Fate in Leishmania Infection. FRONTIERS IN MICROBIOLOGY, v. 8, JAN 15 2018. Web of Science Citations: 12.

ACUNA, STEPHANIE MAIA; AOKI, JULIANA IDE; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; RIBEIRO FERNANDES, JULIANE CRISTINA; MUXEL, SANDRA MARCIA; FLOETER-WINTER, LUCILE MARIA. Arginase expression modulates nitric oxide production in Leishmania (Leishmania) amazonensis. PLoS One, v. 12, n. 11 NOV 14 2017. Web of Science Citations: 10.

AOKI, JULIANA IDE; MUXEL, SANDRA MARCIA; ZAMPIERI, RICARDO ANDRADE; ACUNA, STEPHANIE MAIA; RIBEIRO FERNANDES, JULIANE CRISTINA; VANDERLINDE, RUBIA HELOISA; OLIVEIRA DE PINHO SALES, MARIA CARMEN; FLOETER-WINTER, LUCILE MARIA. L-arginine availability and arginase activity: Characterization of amino acid permease 3 in Leishmania amazonensis. PLoS Neglected Tropical Diseases, v. 11, n. 10 OCT 2017. Web of Science Citations: 10.

AOKI, JULIANA IDE; MUXEL, SANDRA MARCIA; ZAMPIERI, RICARDO ANDRADE; LARANJEIRA-SILVA, MARIA FERNANDA; MULLER, KARL ERIK; NERLAND, AUDUN HELGE; FLOETER-WINTER, LUCILE MARIA. RNA-seq transcriptional profiling of Leishmania amazonensis reveals an arginasedependent gene expression regulation. PLoS Neglected Tropical Diseases, v. 11, n. 10 OCT 2017. Web of Science Citations: 10.

MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; ZAMPIERI, RICARDO ANDRADE; FLOETER-WINTER, LUCILE MARIA. Leishmania (Leishmania) amazonensis induces macrophage miR-294 and miR-721 expression and modulates infection by targeting NOS2 and L-arginine metabolism. SCIENTIFIC REPORTS, v. 7, MAR 9 2017. Web of Science Citations: 26.

MUXEL, SANDRA MARCIA; LARANJEIRA-SILVA, MARIA FERNANDA; CARVALHO-SOUSA, CLAUDIA EMANUELLE; FLOETER-WINTER, LUCILE MARIA; MARKUS, REGINA P. The RelA/cRel nuclear factor-B (NF-B) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages. Journal of Pineal Research, v. 60, n. 4, p. 394-404, MAY 2016. Web of Science Citations: 22.