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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pharmacokinetic disposition of erythraline in rats after intravenous administration

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Author(s):
Demarque, Daniel P. [1] ; Callejon, Daniel R. [1] ; Pinto, Larissa G. [1] ; Gouvea, Dayana R. [1] ; de Moraes, Natalia V. [2] ; Lopes, Joao L. C. [1] ; Lopes, Jose N. C. [3] ; Lopes, Norberto P. [1] ; Guaratini, Thais [3, 1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Fis & Quim, Ribeirao Preto, SP - Brazil
[2] Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Principios Ativos Nat & Toxicol, Araraquara, SP - Brazil
[3] Lychnoflora Pesquisa & Desenvolvimento Prod Nat L, Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 6, p. 773-777, NOV-DEC 2019.
Web of Science Citations: 0
Abstract

ABSTRACT Erythraline is the major alkaloid produced by Erythrina verna Vell., Fabaceae, a plant used in folk medicine and phytotherapeutic products to treat anxiety and sleep disorders. This study aimed to investigate the pharmacokinetic parameters of erythraline after intravenous administration in rats. For the analysis of erythraline in rat plasma, a method was developed and validated using UHPLC-MS/MS. Pharmacokinetic parameters were estimated by non-compartmental analysis. The metabolite 8-oxo-erythraline observed in previous biomimetic model studies was monitored during in vivo experiments. The quantification limit was 5 ng/ml within a linear range of 5-2000 ng/ml. After an intravenous dose of 1 mg/kg, the following pharmacokinetic parameters were observed: elimination half-life of 44.2 min; total clearance of 42.1 ml/min/kg and volume of distribution of 2085 ml/kg. In summary, a precise, accurate and selective UHPLC-MS/MS method was developed and successfully applied to investigate the pharmacokinetics of erythraline in rats. The metabolite 8-oxo-erythraline was observed in rat plasma after 20 min of erythraline administration. (AU)

FAPESP's process: 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation
Grantee:Norberto Peporine Lopes
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 14/18052-0 - Tissue localization of tannins and Anthraquinones acting on gastrointestinal system
Grantee:Daniel Pecoraro Demarque
Support Opportunities: Scholarships in Brazil - Doctorate