| Full text | |
| Author(s): |
dos Santos Silva, Danielly Beraldo
[1, 2]
;
Simielli Fonseca, Larissa Fernanda
[1, 2]
;
Braga Magalhaes, Ana Fabricia
[3]
;
Magalhaes Muniz, Maria Malane
[2]
;
Baldi, Fernando
[1, 2]
;
Ferro, Jesus Aparecido
[1, 2]
;
Loyola Chardulo, Luis Artur
[4]
;
Pinheiro, Daniel Guariz
[2]
;
de Albuquerque, Lucia Galvao
[1, 2]
Total Authors: 9
|
| Affiliation: | [1] Natl Council Sci & Technol Dev CNPq, Brasilia, DF - Brazil
[2] Sao Paulo State Univ, UNESP, Sch Agr & Vet Sci, Jaboticabal, SP - Brazil
[3] Adv Res Ctr Beef Cattle, IZ, Sertaozinho, SP - Brazil
[4] Sao Paulo State Univ, UNESP, Sch Vet & Anim Sci, Botucatu, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Genomics; v. 112, n. 2, p. 1257-1263, MAR 2020. |
| Web of Science Citations: | 2 |
| Abstract | |
This study aimed to use RNA-Seq to identify differentially expressed genes (DEGs) in muscle of uncastrated Nelore males phenotypically divergent for ribeye muscle area (REA). A total of 80 animals were phenotyped for REA, and 15 animals each with the highest REA and the lowest REA were selected for analyses. DEGs found (N = 288) belonging to families related to muscle cell growth, development, motility and proteolysis, such as actin, myosin, collagen, integrin, solute carrier, ubiquitin and kelch-like. Functional analysis showed that many of the significantly enriched gene ontology terms were closely associated with muscle development, growth, and degradation. Through co-expression network analysis, we predicted three hub genes (PPP3R1, FAM129B and UBE2G1), these genes are involved in muscle growth, proteolysis and immune system. The genes expression levels and its biological process found this study may result in differences in muscle deposition, and therefore, Nelore animals with different REA proportions. (AU) | |
| FAPESP's process: | 09/16118-5 - Genomic tools to genetic improvement of direct economic important traits in Nelore cattle |
| Grantee: | Lucia Galvão de Albuquerque |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 15/16850-9 - Differential gene expression associated with traits of carcass and meat in Nelore cattle |
| Grantee: | Danielly Beraldo dos Santos Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate |