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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile

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Author(s):
da Costa Pinaffi, Ana Clara [1] ; Sampaio, Geni Rodrigues [1] ; Soares, Maiara Jurema [1] ; Shahidi, Fereidoon [2] ; de Camargo, Adriano Costa [3] ; Torres, Elizabeth A. F. S. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, 715 Dr Arnaldo Ave, BR-01246904 Sao Paulo, SP - Brazil
[2] Mem Univ Newfoundland, Dept Biochem, St John, NF A1B 3X9 - Canada
[3] Pontificia Univ, Fac Agron & Ingn Forestal, Dept Ciencias Vegetales, Casilla 306-22, Santiago - Chile
Total Affiliations: 3
Document type: Journal article
Source: Molecules; v. 25, n. 3 FEB 1 2020.
Web of Science Citations: 6
Abstract

The Brazilian Food Supplement Law recently recognized that guarana (Paullinia cupana) contains bioactive substances, hence supporting its role as a functional food ingredient. The health benefits of guarana are associated, at least in part, to its phenolic compounds. However, to the best of our knowledge, there is no literature addressing the presence of phenolic compounds in the fraction containing insoluble-bound compounds and its contribution in terms of alpha-glucosidase inhibition. The concentration of phenolic extracts released from the insoluble-bound fraction required to inhibit 50% of alpha-glucosidase (IC50) activity was 5.8-fold lower than that present in the soluble counterpart. Both fractions exhibited a mixed inhibition mode. Fourteen proanthocyanidins (dimers to tetramers) present in the insoluble-bound fraction were tentatively identified by MALDi-TOF-MS. Future studies aiming at increasing the concentration of the soluble counterpart are deemed necessary. The results presented here enhance the phenolic database of guarana and have a practical impact on the procurement of nutraceuticals and functional ingredients related to the prevention and/or management of type 2 diabetes. The Brazilian normative on food supplements has been recently revised. This study lends support to the future inclusion of guarana powder in the list of sources of proanthocyanidins for the industry of food supplements. (AU)

FAPESP's process: 17/20039-0 - Effects of guaraná (Paullinia cupana) on lipid metabolism and bioacessibility of its polyphenols in genes related to the absorption of cholesterol in Caco-2 cells
Grantee:Elizabeth Aparecida Ferraz da Silva Torres
Support Opportunities: Regular Research Grants