Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Use of Ultrasound as a Tool to Evaluate Pulmonary Disease in Cystic Fibrosis

Full text
Author(s):
Peixoto, Andressa O. [1, 2, 3] ; Al Marson, Fernando [1, 2, 4, 5] ; Dertkigil, Sergio Sj [6] ; Dertkigil, Raquel P. [6] ; Souza, Tiago H. [1, 7] ; Fraga, Andrea [1, 3] ; Ribeiro, Antonio F. [1] ; Toro, Adyleia Adc [1, 2] ; Ribeiro, Jose D. [1, 2, 3]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, Dept Pediat, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Lab Pulm Physiol, Ctr Pediat Invest, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Hosp Clin, Urgent & Emergency Care Unit, Campinas, SP - Brazil
[4] Univ Estadual Campinas, Dept Med Genet & Genom Med, Sao Paulo, SP - Brazil
[5] Sao Francisco Univ, Lab Med & Human Genet, Post Grad Program Hlth Sci, Sao Paulo - Brazil
[6] Univ Estadual Campinas, Dept Radiol, Campinas, SP - Brazil
[7] Univ Estadual Campinas, Sch Med Sci, Pediat Intens Care Unit, Sao Paulo, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Respiratory Care; v. 65, n. 3, p. 293-303, MAR 1 2020.
Web of Science Citations: 0
Abstract

BACKGROUND: Lung ultrasound is an examination that allows the assessment of pulmonary involvement by analyzing artifacts. Our primary aim was to correlate our lung ultrasound findings with pulmonary function and the modified Bhalla score in patients with cystic fibrosis. METHODS: Subjects with cystic fibrosis were evaluated based on the results of lung ultrasound, pulmonary function exams (ie, spirometry before and after the use of a bronchodilator and S-pO2), and the modified Bhalla score. The partial correlation set by age between lung ultrasound, pulmonary function, and modified Bhalla score was carried out. Lung ultrasound was graded according to a new score, ranging from 0 to 36, with a higher score being associated with a greater degree of involvement. We performed Bland-Altman and linear regression analysis to identify bias between lung ultrasound and modified Bhalla score. Alpha = 0.05. RESULTS: 18 subjects with cystic fibrosis were included. In partial correlation controlled by age, we observed significant ultrasound score values with weight (partial correlation = -0.579), body mass index (partial correlation = -0.609), S-pO2 (partial correlation = -0.728), FVC% (pre-bronchodilator: partial correlation = -0.538; post-bronchodilator: partial correlation = -0.560), FEV 1 % (pre-bronchodilator: partial correlation = -0.536; post-bronchodilator: partial correlation = -0.546), and modified Bhalla score (partial correlation = 0.607). We did not identify bias between lung ultrasound and modified Bhalla score measured by z-score. CONCLUSIONS: Lung ultrasound seems to be effective and corroborates with high-resolution computed tomography when evaluated by the modified Bha lla score. At the same time, lung ultrasound had significant correlation with pulmonary function and nutritional status. (AU)

FAPESP's process: 11/12939-4 - Association between polymorphisms in modifier genes in children and adolescent with allergic and non-allergic: mild, moderate and severe asthma
Grantee:Fernando Augusto de Lima Marson
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/12183-8 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia
Grantee:Jose Dirceu Ribeiro
Support type: Regular Research Grants
FAPESP's process: 11/18845-1 - Association between polymorphisms in modifier genes in children and adolescent with allergic and non-allergic mild, moderate and severe asthma
Grantee:Jose Dirceu Ribeiro
Support type: Regular Research Grants
FAPESP's process: 15/12858-5 - Identification of prevalent mutations and clinical and functional characterization of children and adults with primary ciliary dyskinesia
Grantee:Fernando Augusto de Lima Marson
Support type: Scholarships in Brazil - Post-Doctorate