Prebiotic potencial of jucara berry on changes in gut bacteria and acetate of individuals with obesity

Author(s)

Jamar, Giovana ^{[1, 2]} ; Santamarina, Aline Boveto ^{[1, 2]} ; Casagrande, Breno Picin ^[1] ; Estadella, Debora ^{[3, 2]} ; de Rosso, Veridiana Vera ^[3] ; Wagner, Roger ^[4] ; Fagundes, Mariane Bittencourt ^[4] ; Pisani, Luciana Pellegrini ^{[3, 2]}

Affiliation

^[1] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Santos, SP - Brazil

^[2] Univ Fed Sao Paulo, Lab Nutr & Fisiol Endocrina LaNFE, Santos, SP - Brazil

^[3] Univ Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Santos, SP - Brazil

^[4] Univ Fed Santa Maria, Ctr Ciencias Rurais, Dept Tecnol & Ciencias Alimentos, Santa Maria, RS - Brazil

• Document type: Journal article
• Source: EUROPEAN JOURNAL OF NUTRITION; v. 59, n. 8 FEB 2020.
• Web of Science Citations: 0

Abstract

Purpose Whole plant foods can be fermentable by SCFA-producing bacteria and positively influence host adipose tissue development and obesity related-metabolic disorders, conferring a prebiotic role. Considering the jucara berry composition, rich in fiber and polyphenols, we hypothesized the probable prebiotic role of jucara in individuals with obesity. Methods It was a randomized double-blind placebo-controlled trial with 35 volunteers with obesity I and II of both sexes aged from 31 to 59 years, divided into jucara group (5 g lyophilized jucara) or placebo group (5 g of maltodextrin) for 6 weeks. Before and after supplementation, food intake and blood and stool samples were collected to evaluate serum LPS, SCFA, and microbial bacteria. Results Significant increase in fecal acetate (g = 0.809; p = 0.038) and in relative abundance of A. muciniphila, Bifidobacterium spp. and C. coccoides were observed in response to jucara supplementation (Delta% = 239.6%, 182.6%, and 214%, respectively), with a significant mediator role of Bifidobacterium spp. in high amounts of fecal acetate (z = 2.925; p = 0.003). To certify the prebiotic role of jucara, the averages were adjusted for total fiber intake; and there was no effect of the fiber intake on the SCFA nor on the intestinal bacteria. Conclusion Jucara berry may haveprebiotic function, with emphasis on the bifidogenic effect, leading to increased excretion of acetate. (AU)

• FAPESP's process: 16/14133-0 - Intracellular mechanisms implicated to inflammatory process in obese subjects before and after supplementation juçara pulp
• Grantee: Luciana Pellegrini Pisani
• Support Opportunities: Regular Research Grants