Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle

Author(s)

Brandao Consolo, Nara Regina ^[1] ; da Silva, Juliana ^[1] ; Macedo Buarque, Vicente Luiz ^[1] ; Higuera-Padilla, Angel ^[2] ; Garibaldi Simon Barbosa, Luis Carlos ^[2] ; Zawadzki, Andressa ^[3] ; Colnago, Luis Alberto ^[2] ; Netto, Arlindo Saran ^[1] ; Gerrard, David Edwin ^[4] ; Silva, Saulo Luz ^[1]

Affiliation

^[1] Univ Sao Paulo, Dept Anim Sci, Duque de Caxias Norte 225, BR-13635900 Pirassununga - Brazil

^[2] EMBRAPA Instrumentacao, Xv Novembro 1452, BR-13560970 Sao Carlos - Brazil

^[3] Univ Copenhagen, Dept Food Sci, Rolighedsvej 26, DK-1958 Frederiksberg - Denmark

^[4] Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA 24061 - USA

• Document type: Journal article
• Source: METABOLITES; v. 10, n. 2 FEB 2020.
• Web of Science Citations: 0

Abstract

To clarify the relationship between beef genetic selection for growth and precocity with muscle metabolism and metabolites, we performed metabolomic analysis using Longissimus lumborum (LL) muscle from Nellore cattle with divergent selection for these traits (high growth, HG; low growth, LG; high precocity, HP; low precocity, LP). Genetic potential for growth affected muscle protein and energetic metabolism. HG animals had a high concentration of arginine, carnosine, and leucine compared to LG animals. HP animals presented a high concentration of glutamine, betaine, creatinine, isoleucine, carnitine, acetyl carnitine, and lower levels of glucose compared to LP animals, affecting protein and fatty acid metabolism. Intensity of selection (high or low) was correlated with changes in protein metabolism, and the type of selection (growth or precocity) affected fat metabolism. In conclusion, both HG and HP appear to be correlated with a high concentration of protein metabolites and changes in protein metabolic pathways, while selection for precocity is more correlated with changes in fat metabolism compared to animals selected for growth. (AU)

• FAPESP's process: 16/01320-7 - Metabolomic characterization of blood and meat from young Nellore bulls, progeny of bulls with different EPDs for growth, precocity and muscularity
• Grantee: Nara Regina Brandão Cônsolo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 16/17433-5 - Study of relationship among expected progeny differences (EPD) with productive and meat quality traits of Nelore cattle
• Grantee: Saulo da Luz e Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/09800-3 - Metabolomics characterization of sheep and cattle meat
• Grantee: Nara Regina Brandão Cônsolo
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor