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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polyionic complexes of chitosan-N-arginine with alginate as pH responsive and mucoadhesive particles for oral drug delivery applications

Full text
Author(s):
Fernandes Patta, Ana C. M. [1] ; Mathews, Patrick D. [1] ; Madrid, Rafael R. M. [1] ; Rigoni, Vera L. S. [1] ; Silva, Emerson R. [1] ; Mertins, Omar [1]
Total Authors: 6
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Paulista Med Sch, Dept Biophys, LNBM, BR-04023062 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: International Journal of Biological Macromolecules; v. 148, p. 550-564, APR 1 2020.
Web of Science Citations: 0
Abstract

The production of efficient micro and nanoparticles of pH-responsive and mucoadhesive properties is of high scrutiny. We produced a drug carrier bioparticle providing such structural features. Thereby, protonated chitosan bearing chemically bonded arginine was interacted with ionized alginate, leading to the assembling of colloidal particles of specific characteristics. Ideally, the ratio of chitosan-arginine monomers to alginate monomer is 1.6 when the biopolymers are highly charged, providing electrostatic interaction with Gibbs energy compensation around similar to 14 kcal/mol. Both size and surface charge of the bioparticle respond to pH variation, leading to structures of nano to micro hydrodynamic diameters and of positive, nearly neutral and negative zeta potential, with nanoscopic structure changing from mass to surface fractals. The inclusion of two hydrophobic model drugs provided some specific physicochemical features. Following freeze-drying, the bioparticles present both irregular shape and surface morphology, but an overall similar dry structure. An in vivo study of oral administration to teleost fish revealed that the bioparticles attain the intestine mucus and further, the interaction with the intestinal mucosa is timely dependent thanks to the mucoadhesive property. The in vivo study endorsed that the bioparticle provides high compliance to freshwater ornamental fish, highlighting it as a material of promising application. (C) 2020 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 16/13368-4 - Nanostructured systems: from membrane biomimetic models to carriers of bioactives
Grantee:Karin Do Amaral Riske
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/16722-6 - pH responsive nanoparticles for optimization of oral delivery of antiparasite drugs in the treatment of ornamental fish
Grantee:Ana Carolina Monge Fernandes Patta
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/20482-3 - Diversity of microscopic cnidarians from the Amazon Basin with emphasis on phylogeny, systematic and interaction with their hosts
Grantee:Patrick Mathews Delgado
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 15/23948-5 - Improvement of the polysaccharide chitosan properties for its application in liposomes and giant vesicles
Grantee:Omar Mertins
Support Opportunities: Regular Research Grants
FAPESP's process: 16/24409-3 - Cell-Penetrating Peptides for Transport of Plasmid DNA and microRNA: from Nanoscopic Structure to Gene Delivery.
Grantee:Emerson Rodrigo da Silva
Support Opportunities: Regular Research Grants