Ovarian status modulates cardiovascular autonomic control and oxidative stress in target organs

Author(s)

Ferreira, Maycon Junior ^[1] ; Sanches, Iris Callado ^[2] ; Jorge, Luciana ^[3] ; Llesuy, Susana Francisca ^[4] ; Irigoyen, Maria Claudia ^[3] ; De Angelis, Katia ^{[1, 5]}

Affiliation

^[1] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Physiol Exercise Lab, Sao Paulo - Brazil

^[2] Sao Judas Tadeu Univ USJT, Human Movement Lab, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Heart Inst, Hypertens Unit, Sao Paulo - Brazil

^[4] Univ Inst Italian Hosp, Italian Hosp Buenos Aires HIBA, Buenos Aires, DF - Argentina

^[5] Nove de Julho Univ UNINOVE, Lab Translat Physiol, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: BIOLOGY OF SEX DIFFERENCES; v. 11, n. 1 APR 7 2020.
• Web of Science Citations: 0

Abstract

Studies have presented conflicting findings regarding the association between both fluctuation and deprivation of ovarian hormones and cardiovascular autonomic modulation and oxidative stress and their potential impact on resting arterial pressure (AP) and cardiovascular risk. This study aimed to assess cardiovascular autonomic modulation, baroreflex sensitivity (BRS), and oxidative stress in male rats (M) and in female rats during ovulatory (FOV) and non-ovulatory phases (FNOV) of the estrous cycle and after deprivation of ovarian hormones (FO). Direct AP was recorded, and BRS was assessed by using increasing doses of phenylephrine and sodium nitroprusside. AP and heart rate variability were assessed by spectral analysis. Oxidative stress profile was evaluated in cardiac, renal, and muscle tissues. In females, the ovulatory phase and ovarian hormone deprivation induced an increase in AP (FOV and FO similar to 9 mmHg) when compared to the non-ovulatory phase. Ovariectomy promoted increased cardiac sympathovagal balance (similar to 17-37%) when compared to other groups. Both FOV and FO groups presented impaired BRS, associated with higher AP variability. In general, antioxidant capacity was higher in the FNOV than in the M group. Ovarian hormone deprivation induced a decrease in catalase activity in cardiac and renal tissues and an increase in lipid peroxidation in all tissues analyzed. Positive correlations (p < 0.05) were found between vascular sympathetic modulation and lipid peroxidation in cardiac (r = 0.60), renal (r = 0.60), and muscle (r = 0.57) tissues. In conclusion, both oscillation and deprivation of ovarian hormones play an important role in cardiovascular autonomic control and oxidative stress profile in target organs, which is reflected in AP changes. (AU)

• FAPESP's process: 18/17183-4 - Fructose overload in genitors: impact of exercise training on cardiometabolic and neuroimmune changes in offspring
• Grantee: Kátia de Angelis Lobo D Avila
• Support Opportunities: Regular Research Grants