Three plasma metabolites in elderly patients differentiate mild cognitive impairment and Alzheimer's disease: a pilot study

Author(s)

Costa, Alana C. ^{[1, 2]} ; Joaquim, Helena P. G. ^{[1, 2]} ; Forlenza, V, Orestes ; Gattaz, Wagner F. ^{[3, 4]} ; Talib, Leda L. ^{[3, 4]}

Affiliation

^[1] Univ Sao Paulo, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Fac Med, Rua Dr Ovidio Pires de Campos 785, 3 Andar, BR-05403010 Sao Paulo - Brazil

^[2] Conselho Nacl Dev Cientif & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INBioN, Sao Paulo - Brazil

^[3] Forlenza, Orestes, V, Univ Sao Paulo, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Fac Med, Rua Dr Ovidio Pires de Campos 785, 3 Andar, BR-05403010 Sao Paulo - Brazil

^[4] Forlenza, Orestes, V, Conselho Nacl Dev Cientif & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria INBioN, Sao Paulo - Brazil

• Document type: Journal article
• Source: EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE; v. 270, n. 4, p. 483-488, JUN 2020.
• Web of Science Citations: 0

Abstract

The metabolomic profile of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) may suggest potential diagnostic biomarkers and provide information on the pathophysiology of dementia. Our aim was to quantify plasmatic metabolites of AD patients, MCI and controls. We investigated the metabolomic profile-using the AbsoluteIDQ (R) p180 assay-of 79 older adults with primary cognitive impairment (34 AD and 20 MCI) and 25 healthy elders (controls). A cluster analysis revealed that a combination C12-DC, C12 and PCaaC26:0 could differentiate the patients according to diagnostic. Future studies should combine metabolomic profiles with other biomarkers to identify diagnostic groups. (AU)

• FAPESP's process: 14/50873-3 - INCT 2014: National Institute of Biomarkers in Neuropsychiatry
• Grantee: Wagner Farid Gattaz
• Support type: Research Projects - Thematic Grants
• FAPESP's process: 14/20913-3 - Determination of plasma phospholipids in neuropsychiatric disorders
• Grantee: Alana Caroline Costa
• Support type: Scholarships in Brazil - Master