Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genome constellations of rotavirus a isolated from avian species in Brazil, 2008-2015

Full text
Author(s):
Beserra, Laila A. R. [1] ; Barbosa, Carla M. [2] ; Berg, Mikael [3] ; Brandao, Paulo E. [1] ; Soares, Rodrigo M. [1] ; Gregori, Fabio [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med, Dept Prevent Vet Med & Anim Hlth, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Av Prof Dr Prof Lineu Prestes 1374, BR-05508900 Sao Paulo, SP - Brazil
[3] Swedish Univ Agr Sci SLU BVF, Dept Biomed Sci & Vet Publ Hlth, Box 7028, S-75007 Uppsala - Sweden
Total Affiliations: 3
Document type: Journal article
Source: Brazilian Journal of Microbiology; v. 51, n. 3 MAY 2020.
Web of Science Citations: 0
Abstract

Rotaviruses are members of the family Reoviridae and are a common cause of acute diarrhea in many mammalian and avian species. They are non-enveloped icosahedral particles and their genome comprises 11 segments of double-stranded RNA, which encodes six structural proteins (VP1-4, VP6-7) and six nonstructural proteins (NSP1-6). Genotypes are defined based upon the diversity found in these genes and viral characterization plays a central role on epidemiological studies and prevention. Here we investigate the distribution of Brazilian RVAs genotypes in 8 chicken samples collected between 2008 and 2015 from different regions by RT-PCR, partial (Sanger) nucleotide sequencing and phylogenetic analysis from all rotavirus genes. Although the identified genotypes were typical from avian host species, when analyzed together, they form novel genetic constellations: G19-P{[}31]-I11-R6-C6-M7-A16-N6-T8-E10-H8 and G19-P{[}31]-I4-R4-C4-M4-A16-N4-T4-E4-H4. This study highlights that avian rotaviruses are widespread among commercial farms in Brazil, and the co-circulation of at least two different genomic constellations indicates that may present a way bigger genetic variability, that can be increased by the possible transmission events from other birds, lack of specific preventive measures, as well as the different viral evolution mechanisms. (AU)

FAPESP's process: 14/13531-7 - Multigenic analysis of avian group a rotavirus from Brazilian poultry farms
Grantee:Fábio Gregori
Support Opportunities: Regular Research Grants