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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Methylone screening with electropolymerized molecularly imprinted polymer on screen-printed electrodes

Full text
Author(s):
Couto, Rosa A. S. [1] ; Mounssef Jr, Bassim ; Carvalho, Felix [2] ; Rodrigues, Cecilia M. P. [3] ; Braga, Ataualpa A. C. [4] ; Aldous, Leigh [5] ; Goncalves, Luis Moreira [4] ; Quinaz, M. Beatriz [1]
Total Authors: 8
Affiliation:
[1] Univ Porto, Fac Pharm, Dept Chem Sci, Lab Appl Chem, REQUIMTE LAQV, Porto - Portugal
[2] Univ Porto, Fac Pharm, Dept Biol Sci, Lab Toxicol, REQUIMTE UCIBIO, Porto - Portugal
[3] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Lisbon - Portugal
[4] Mounssef Jr, Jr., Bassim, Univ Sao Paulo, Dept Quim Fundamental, Inst Quim, Sao Paulo, SP - Brazil
[5] Kings Coll London, Dept Chem, London - England
Total Affiliations: 5
Document type: Journal article
Source: SENSORS AND ACTUATORS B-CHEMICAL; v. 316, JUL 15 2020.
Web of Science Citations: 0
Abstract

Methylone (also known as bk-MDMA) is a substituted cathinone developed to elicit similar psychotropic effects as 4-methylenedioxymethamphetamine (MDMA, also known as ecstasy). Although methylone is a scheduled substance, its specific structural features means it generally cannot be detected and quantified using the same conditions commonly employed for ecstasy. This work therefore describes the development of an electroanalytical method for the selective quantification of methylone. This method uses an electropolymerized molecularly imprinted polymer (MIP) on the surface of screen-printed gold electrodes (SPAuEs), using 2-mercaptobenzimidazole (2-MBI) as the building monomer and methylone as the analyte template. The construction and optimization of the SPAuE-MIP sensor was studied, step-by-step, using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Additionally, the direct electrooxidation of methylone was investigated, and methylone-MIP interactions probed computationally. Ultimately, square-wave voltammetry (SWV) quantification of methylone using the SPAuE-MIP sensor was demonstrated to be both sensitive and selective. The electroanalytical determination showed suitable analytical parameters as: intra-day repeatability of 1.5%, a limit of detection (LOD) of 1.1 mu mol L-1 (0.23 mg L-1) and a linear range up to 50 mu mol L-1 (ca. 10 mg dL(-1)) with an r(2) of 0.996, as well as much higher currents towards the analyte than similar compounds and commonly present interferents. (AU)

FAPESP's process: 15/01491-3 - Theoretical study of cross-coupling reactions: homogeneous and heterogeneous catalysis
Grantee:Ataualpa Albert Carmo Braga
Support Opportunities: Regular Research Grants
FAPESP's process: 14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes
Grantee:Carlos Roque Duarte Correia
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/14425-7 - A new synergetic path for gas-diffusion microextraction (GDME) making use of molecular imprinted polymers (MIPs)
Grantee:Luís Francisco Moreira Gonçalves
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 19/05569-8 - Towards biothermoelectrochemistry: using enzymes to harvest energy from waste heat
Grantee:Luís Francisco Moreira Gonçalves
Support Opportunities: Research Grants - Visiting Researcher Grant - International