| Full text | |
| Author(s): |
Prospero, Andre G.
[1]
;
Fidelis-de-Oliveira, Patricia
[2]
;
Soares, Guilherme A.
[1]
;
Miranda, Milena F.
[1]
;
Pinto, Leonardo A.
[1]
;
dos Santos, Daniela C.
[3]
;
Silva, Vanessa dos S.
[4]
;
Zufelato, Nicholas
[5]
;
Bakuzis, Andris F.
[5]
;
Miranda, Jose R. A.
[1]
Total Authors: 10
|
| Affiliation: | [1] Univ Estadual Paulista, Dept Fis & Biofis, IBB, BR-18618689 Botucatu, SP - Brazil
[2] Univ Estadual Paulista, Dept Fisiol, IBB, BR-18618689 Botucatu, SP - Brazil
[3] Univ Estadual Paulista, Dept Patol, BR-18618689 Botucatu, SP - Brazil
[4] Univ Estadual Paulista, Dept Clin Med, BR-18618689 Botucatu, SP - Brazil
[5] Univ Fed Goias, Inst Fis, Alameda Palmeiras St, BR-74690900 Goiania, Go - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Nanomedicine; v. 15, n. 5, p. 509-525, FEB 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Aim: This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys. Materials \& methods: We used the ACB to detect the MNP kidney perfusion in vivo. Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution. Results: We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved. Conclusion: This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine. Graphical abstract (AU) | |
| FAPESP's process: | 15/14923-9 - Instrumentation and applications by biosusceptometry alternating current: nanoparticles distribution studies, motility and quality control of solid dosage forms |
| Grantee: | José Ricardo de Arruda Miranda |
| Support Opportunities: | Regular Research Grants |