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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Response of the Human Milk Microbiota to a Maternal Prebiotic Intervention Is Individual and Influenced by Maternal Age

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Author(s):
Padilha, Marina [1, 2] ; Brejnrod, Asker [3] ; Danneskiold-Samsoe, Niels Banhos [3] ; Hoffmann, Christian [1, 2] ; Iaucci, Julia de Melo [1] ; Cabral, Vanessa Pereira [1, 4] ; Xavier-Santos, Douglas [1, 5] ; Taddei, Carla Romano [1, 6] ; Kristiansen, Karsten [3] ; Isay Saad, Susana Marta [1, 2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Sao Paulo 05508000 - Brazil
[2] Univ Sao Paulo, Food Res Ctr FoRC, Sao Paulo 05508000 - Brazil
[3] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, DK-2100 Copenhagen - Denmark
[4] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo 01246904 - Brazil
[5] Fac High Educ Interior Sao Paulo, Marilia 17512130, SP - Brazil
[6] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo 03828000 - Brazil
Total Affiliations: 6
Document type: Journal article
Source: NUTRIENTS; v. 12, n. 4 APR 2020.
Web of Science Citations: 0
Abstract

Maternal bacteria are shared with infants via breastfeeding. Prebiotics modulate the gut microbiota, promoting health benefits. We investigated whether the maternal diet supplementation with a prebiotic (fructooligosaccharides, FOS) could influence the milk microbiota. Twenty-eight lactating women received 4.5 g of fructooligosaccharides + 2 g of maltodextrin (FOS group) and twenty-five received 2 g of maltodextrin (placebo group) for 20 days. Breast-milk samples were taken before and after the intervention. The DNA from samples was used for 16S rRNA sequencing. No statistical differences between the groups were found for the bacterial genera after the intervention. However, the distances of the trajectories covered by paired samples from the beginning to the end of the supplementation were higher for the FOS group (p = 0.0007) indicating greater changes in milk microbiota compared to the control group. Linear regression models suggested that the maternal age influenced the response for FOS supplementation (p = 0.02). Interestingly, the pattern of changes to genus abundance upon supplementation was not shared between mothers. We demonstrated that manipulating the human milk microbiota through prebiotics is possible, and the maternal age can affect this response. (AU)

FAPESP's process: 13/07914-8 - FoRC - Food Research Center
Grantee:Bernadette Dora Gombossy de Melo Franco
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/26435-3 - Impact of the maternal diet and the intervention with fructooligosaccharide on the human milk microbiota.
Grantee:Marina Padilha
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/07936-0 - Human milk microbiota analysis by next-generation sequencing: the impact of maternal diet and the intervention with fructooligosaccharides
Grantee:Marina Padilha
Support type: Scholarships abroad - Research Internship - Doctorate