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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mechanical-chemical coupling in Temporomandibular Joint disc

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Author(s):
do Nascimento, Rodney Marcelo [1, 2, 3] ; Baldit, Adrien [3] ; Kokanyan, Ninel [4, 5] ; Tappert, Lara Kristin [3] ; Lipinski, Paul [3] ; Hernandes, Antonio Carlos [2] ; Rahouadj, Rachid [3]
Total Authors: 7
Affiliation:
[1] Univ Fed Santa Catarina, Dept Fis, BR-88040900 Florianopolis, SC - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13566590 Sao Paulo - Brazil
[3] Univ Lorraine Nancy Metz, Lab Etud Microstruct Mecan Mat & Vivant, LEM3 UMR CNRS 7239, F-57070 Nancy - France
[4] Univ Paris Saclay, Lab Mat Opt Photon & Syst LMOPS, Cent Supelec, 2 Rue E, F-57070 Metz - France
[5] Univ Lorraine, Lab Mat Opt Photon & Syst LMOPS, EA 4423, 2 Rue E Belin, F-57070 Metz - France
Total Affiliations: 5
Document type: Journal article
Source: MATERIALIA; v. 9, MAR 2020.
Web of Science Citations: 0
Abstract

This paper reports an experimental investigation based on vibrational spectroscopy of biological materials by a new custom-made device allowing simultaneously applying tensile load with changes within a controlled chemical environment. The response of the molecular structures of Temporomandibular Joint (TMJ) discs under simulated daily mechanical stimulations was characterized by stress-strain analysis and Raman spectra. The results show that changes in the biochemical environment around tissue (associated to common disorders) led to significant modifications to its mechanical properties. The molecular response to stress was then fully characterized by a combination of molecular mapping followed by statistical analysis via Principal Component Analysis resulting in the identification of the phenylalanine-aromatic amino acids as a significant mechanical-chemical effector of TMJ discs. The coupled tensile machine and vibrational spectroscopy approach enabling in-situ molecular studies proves to be a powerful technique for biological material characterization and tissue engineering. (AU)

FAPESP's process: 17/03842-3 - Study of the Guided Tissue Regeneration (GTR) through experimental analysis in temporo-mandibular joint's disc and NR-CaP occlusive membranes
Grantee:Rodney Marcelo do Nascimento
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 13/21970-8 - Development of biomaterial from the incorporation of calcium phosphates in latex structures to order application as controlled release device
Grantee:Rodney Marcelo do Nascimento
Support Opportunities: Scholarships in Brazil - Post-Doctoral