| Full text | |
| Author(s): |
da Silva, Larissa Gomes
[1]
;
Martins, Maira Pompeu
[1]
;
Sanches, Pablo Rodrigo
[1]
;
de Aguiar Peres, Nalu Teixeira
[2]
;
Martinez-Rossi, Nilce Maria
[1]
;
Rossi, Antonio
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Fed Minas Gerais, Dept Microbiol, Belo Horizonte, MG - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Brazilian Journal of Microbiology; v. 51, n. 4 JUN 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Fungal growth and development depend on adaptation to the particular pH of their environment. Ambient pH sensing implies the activation of thepacCsignaling pathway, which then acts as a critical regulator for different physiological conditions. The PacC transcription factor may also be associated with the control of salt stress tolerance. In a pH-dependent manner, salinity stress is surpassed by changes in gene expression and coordinated activation of other signaling pathways, thus permitting survival in the challenging environment. In this study, we assessed the regulatory role ofTrichophyton interdigitalePacC in response to pH variation and salinity stress. By employing gene expression analysis, we evaluated the influence of PacC in the modulation of salt stress-related genes, including the transcription factorscrz1,egr2, and the MAP kinasehog1in the dermatophyteT. interdigitale. In our analysis, we also included the evaluation of a potassium/sodium efflux P-type ATPase aiming to identify the role of PacC on its ion pumping activity.Here we demonstrated that salinity stress and buffered pH conditions might affect thepacCgene modulation in the dermatophyteT. interdigitale. (AU) | |
| FAPESP's process: | 09/08411-4 - Functional characterization of genes from the pathogenic fungus Trichophyton rubrum during interaction with host microenvironment cells and molecules. |
| Grantee: | Nalu Teixeira de Aguiar Peres |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 10/15017-8 - Functional characterization of the transcription factor ACE2 of the dermatophyte Trichophyton rubrum and its implication in the host-pathogen interaction |
| Grantee: | Larissa Gomes da Silva |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/03847-7 - Molecular characterization of mechanisms involved in pathogenicity and cell signaling in fungi |
| Grantee: | Nilce Maria Martinez-Rossi |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/11319-1 - Transcription factors and cell signaling. |
| Grantee: | Maíra Pompeu Martins |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |