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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity

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Goncalves Neto, Geraldo S. [1] ; da Costa, Romario P. [2] ; Zanini, Camila L. [3] ; Aguiar, Anna Caroline C. [3] ; de Souza, Juliana O. [3] ; de Souza, Guilherme E. [3] ; Severino, Richele P. [1, 4] ; Cass, Quezia B. [2] ; Cruz, Fabio C. [5] ; Oliva, Glaucius [3] ; Guido, Rafael V. C. [3] ; de Sousa, Lorena R. F. [1, 4]
Total Authors: 12
Affiliation:
[1] Univ Fed Goias, Unidade Acad Especial Quim, BR-75704020 Catalao, Go - Brazil
[2] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13563120 Sao Carlos, SP - Brazil
[4] Cruz, Fabio C., Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo, SP, Brazil.Goncalves Neto, Geraldo S., Univ Fed Goias, Unidade Acad Especial Quim, BR-75704020 Catalao, Go - Brazil
[5] Univ Fed Sao Paulo, Dept Farmacol, BR-04023062 Sao Paulo, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 31, n. 7, p. 1475-1484, JUL 2020.
Web of Science Citations: 0
Abstract

Qualea grandiflora Mart. (“pau-terra”) is a medicinal plant symbolic from Cerrado biome. Qualea species reportedly have antiparasitic properties, but their active compounds have yet to be identified. In this study, we investigated the antiplasmodial activity of Q. grandiflora fruit and stem extracts against Plasmodium falciparum. The polar extracts of both fruits and stems showed promising in vitro antiplasmodial activity against sensitive and resistant P. falciparum strains (half-maximal inhibitory concentration (IC50) = 1.2 and 4.2 ng mL-1, respectively), low cytotoxicity against human hepatic cells (IC50HepG2 ≥ 400 ng mL-1), and a noteworthy selectivity index (SI ≥ 322 and ≥ 96, respectively). The fruit ethanolic extract revealed significant oral efficacy at 100 mg kg-1 in a mouse model of P. berghei malaria (100% reduction in parasitemia on day 5 post-infection). To investigate the chemical composition of the extracts, we developed a method involving liquid chromatography-high resolution quadrupole-time of flight mass spectrometer. The chemical profiling of active extracts indicated 32 compounds, including gallotannins, ellagic acid derivatives and flavonoids. The common component in the active polar extracts was found to be ellagic acid (EA), which may contribute favorably to the in vitro and in vivo inhibitory activity observed in this study. (AU)

FAPESP's process: 13/01710-1 - Enzyme ligand: new models of screening
Grantee:Quezia Bezerra Cass
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC