| Full text | |
| Author(s): Show less - |
Banzato, Thais P.
[1, 2]
;
Gubiani, Juliana R.
[3]
;
Bernardi, Darlon I.
[3]
;
Nogueira, Claudio R.
[4]
;
Monteiro, Afif F.
[3]
;
Juliano, Fernanda F.
[5]
;
de Alencar, Severino M.
[5]
;
Pilli, Ronaldo A.
[6]
;
de Lima, Carolina A.
[7]
;
Longato, Giovanna B.
[7]
;
Ferreira, Antonio G.
[8]
;
Foglio, Mary Ann
[9, 2]
;
de Carvalho, Joao E.
[9, 2]
;
Vendramini-Costa, Debora B.
[10]
;
Berlinck, Roberto G. S.
[3]
Total Authors: 15
|
| Affiliation: | [1] Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Chem Biol & Agr Pluridisciplinary Res Ctr, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[4] Fed Univ Grande Dourados, Fac Sci & Technol, BR-79804970 Dourados, MS - Brazil
[5] Univ Sao Paulo, Dept Agrifood Ind Food & Nutr, Piracicaba, SP - Brazil
[6] Univ Estadual Campinas, Inst Quim, Campinas, SP - Brazil
[7] Univ Sao Francisco, Lab Pesquisa Biol Celular & Mol Tumores & Compost, Braganca Paulista, SP - Brazil
[8] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[9] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil
[10] Fox Chase Canc Ctr, Canc Biol Program, 7701 Burholme Ave, Philadelphia, PA 19111 - USA
Total Affiliations: 10
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 83, n. 6, p. 1784-1793, JUN 26 2020. |
| Web of Science Citations: | 6 |
| Abstract | |
Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (1-4), with a 3-[3-{[}(2-phenylbenzofuran-3-yl)methyl]phenyl]chromane skeleton; propolonones A-C (5-7), with a 3-{[}3-(3-benzylbenzofuran-2-yl)phenyl]-chromane skeleton; and propolol A (8), with a 6-(3-benzyl-benzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin. (AU) | |
| FAPESP's process: | 13/24416-1 - Anticancer and anti-inflammatory activity of red propolis and its bioactive compounds. |
| Grantee: | Thais Petrochelli Banzato |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer |
| Grantee: | Juliana Regina Gubiani |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/06137-6 - Bioprospecting for natural compounds and bioactive derivatives with potent anticancer activity: in vitro/in vivo assays and investigation into the mechanism of action. |
| Grantee: | Giovanna Barbarini Longato |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |