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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis

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Author(s):
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Banzato, Thais P. [1, 2] ; Gubiani, Juliana R. [3] ; Bernardi, Darlon I. [3] ; Nogueira, Claudio R. [4] ; Monteiro, Afif F. [3] ; Juliano, Fernanda F. [5] ; de Alencar, Severino M. [5] ; Pilli, Ronaldo A. [6] ; de Lima, Carolina A. [7] ; Longato, Giovanna B. [7] ; Ferreira, Antonio G. [8] ; Foglio, Mary Ann [9, 2] ; de Carvalho, Joao E. [9, 2] ; Vendramini-Costa, Debora B. [10] ; Berlinck, Roberto G. S. [3]
Total Authors: 15
Affiliation:
[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Chem Biol & Agr Pluridisciplinary Res Ctr, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil
[4] Fed Univ Grande Dourados, Fac Sci & Technol, BR-79804970 Dourados, MS - Brazil
[5] Univ Sao Paulo, Dept Agrifood Ind Food & Nutr, Piracicaba, SP - Brazil
[6] Univ Estadual Campinas, Inst Quim, Campinas, SP - Brazil
[7] Univ Sao Francisco, Lab Pesquisa Biol Celular & Mol Tumores & Compost, Braganca Paulista, SP - Brazil
[8] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil
[9] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil
[10] Fox Chase Canc Ctr, Canc Biol Program, 7701 Burholme Ave, Philadelphia, PA 19111 - USA
Total Affiliations: 10
Document type: Journal article
Source: Journal of Natural Products; v. 83, n. 6, p. 1784-1793, JUN 26 2020.
Web of Science Citations: 0
Abstract

Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (1-4), with a 3-[3-{[}(2-phenylbenzofuran-3-yl)methyl]phenyl]chromane skeleton; propolonones A-C (5-7), with a 3-{[}3-(3-benzylbenzofuran-2-yl)phenyl]-chromane skeleton; and propolol A (8), with a 6-(3-benzyl-benzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin. (AU)

FAPESP's process: 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands
Grantee:Roberto Gomes de Souza Berlinck
Support type: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 13/24416-1 - Anticancer and anti-inflammatory activity of red propolis and its bioactive compounds.
Grantee:Thais Petrochelli Banzato
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/06137-6 - Bioprospecting for natural compounds and bioactive derivatives with potent anticancer activity: in vitro/in vivo assays and investigation into the mechanism of action.
Grantee:Giovanna Barbarini Longato
Support type: Regular Research Grants
FAPESP's process: 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer
Grantee:Juliana Regina Gubiani
Support type: Scholarships in Brazil - Post-Doctorate