Antiproliferative Flavanoid Dimers Isolated from Brazilian Red Propolis

Author(s):Show less -

Banzato, Thais P. ^{[1, 2]} ; Gubiani, Juliana R. ^[3] ; Bernardi, Darlon I. ^[3] ; Nogueira, Claudio R. ^[4] ; Monteiro, Afif F. ^[3] ; Juliano, Fernanda F. ^[5] ; de Alencar, Severino M. ^[5] ; Pilli, Ronaldo A. ^[6] ; de Lima, Carolina A. ^[7] ; Longato, Giovanna B. ^[7] ; Ferreira, Antonio G. ^[8] ; Foglio, Mary Ann ^{[9, 2]} ; de Carvalho, Joao E. ^{[9, 2]} ; Vendramini-Costa, Debora B. ^[10] ; Berlinck, Roberto G. S. ^[3]

Affiliation

^[1] Univ Estadual Campinas, Dept Struct & Funct Biol, Inst Biol, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Chem Biol & Agr Pluridisciplinary Res Ctr, Campinas, SP - Brazil

^[3] Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP - Brazil

^[4] Fed Univ Grande Dourados, Fac Sci & Technol, BR-79804970 Dourados, MS - Brazil

^[5] Univ Sao Paulo, Dept Agrifood Ind Food & Nutr, Piracicaba, SP - Brazil

^[6] Univ Estadual Campinas, Inst Quim, Campinas, SP - Brazil

^[7] Univ Sao Francisco, Lab Pesquisa Biol Celular & Mol Tumores & Compost, Braganca Paulista, SP - Brazil

^[8] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[9] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil

^[10] Fox Chase Canc Ctr, Canc Biol Program, 7701 Burholme Ave, Philadelphia, PA 19111 - USA

• Document type: Journal article
• Source: Journal of Natural Products; v. 83, n. 6, p. 1784-1793, JUN 26 2020.
• Web of Science Citations: 0

Abstract

Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (1-4), with a 3-[3-{[}(2-phenylbenzofuran-3-yl)methyl]phenyl]chromane skeleton; propolonones A-C (5-7), with a 3-{[}3-(3-benzylbenzofuran-2-yl)phenyl]-chromane skeleton; and propolol A (8), with a 6-(3-benzyl-benzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin. (AU)

• FAPESP's process: 13/50228-8 - Biodiversity components, and its metabolic characters, of Brazilian Islands
• Grantee: Roberto Gomes de Souza Berlinck
• Support type: BIOTA-FAPESP Program - Thematic Grants
• FAPESP's process: 13/24416-1 - Anticancer and anti-inflammatory activity of red propolis and its bioactive compounds.
• Grantee: Thais Petrochelli Banzato
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 16/06137-6 - Bioprospecting for natural compounds and bioactive derivatives with potent anticancer activity: in vitro/in vivo assays and investigation into the mechanism of action.
• Grantee: Giovanna Barbarini Longato
• Support type: Regular Research Grants
• FAPESP's process: 17/06014-4 - New secondary metabolites of endophytic and marine organisms as proteasome inhibitors: a validated target against cancer
• Grantee: Juliana Regina Gubiani
• Support type: Scholarships in Brazil - Post-Doctorate