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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Miniaturization of liquid chromatography coupled to mass spectrometry. 2. Achievements on modern instrumentation for miniaturized liquid chromatography coupled to mass spectrometry

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Author(s):
Vargas Medina, Deyber Arley [1] ; Soares Maciel, Edvaldo Vasconcelos [1] ; de Toffoli, Ana Lucia [1] ; Lancas, Fernando Mauro [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sao Carlos Inst Chem, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: TRAC-TRENDS IN ANALYTICAL CHEMISTRY; v. 128, JUL 2020.
Web of Science Citations: 0
Abstract

Capillary and nano liquid chromatography coupled to mass spectrometry has recently become one of the primary analytical techniques in many science areas of maior interest, including omics, food security, environmental surveillance, biomedicine, among others. This interest relays on their economical, environmental and analytical advantages, such as low volumes of reagents and sample requirement, gains on chromatographic performance, and enhanced MS sensitivity. In recent decades significant achievements in instrumentation have been reported, which are increasing the scope of applications based on this technique. Nowadays, miniaturized LC instruments with different setups are commercially available or being in-house developed. In brief, this work summarizes the main characteristics of them, underscoring the main parts of the benchtop systems. For this reason, specific topics are discussing the main advantages and challenges of pumping, injection, and detection modules as well as tubing and connectors. Moreover, considering the higher compatibility between miniaturized LC and MS, this coupling provides higher ionization efficiency improving the analytical results, when compared to conventional LC-MS. Consequently, the essential characteristics of atmospheric pressure ionization for miniaturized LC-MS were highlighted, and a discussion regarding the current state-of-art about the use of electron ionization is also presented. In short, this work underlines the main factors related to instrumental advancements and its consequent influence on analytical methods based on miniaturized LC coupled to mass spectrometry. (C) 2020 Published by Elsevier B.V. (AU)

FAPESP's process: 17/02147-0 - Single drop chromatography and its coupling to mass spectrometry: instrumental strategies, development of materials, automation and analytical applications
Grantee:Fernando Mauro Lanças
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/15462-5 - Employment of graphene as sorbent in miniaturized sample preparation techniques.
Grantee:Bruno Henrique Fumes
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/07347-9 - Development of novel materials and devices for miniaturized sample preparation techniques in the area of food safety
Grantee:Fernando Mauro Lanças
Support Opportunities: Regular Research Grants
FAPESP's process: 19/22724-7 - Novel instrumental approaches for automated and miniaturized analytical methods for the detection of organic compounds by liquid chromatography coupled to mass spectrometry
Grantee:Deyber Arley Vargas Medina
Support Opportunities: Scholarships in Brazil - Post-Doctoral