| Full text | |
| Author(s): Show less - |
de Oliveira, Paula Gabriela Faciola Pessoa
[1, 2, 3]
;
Bonfante, Estevam A.
[4]
;
Bergamo, Edmara T. P.
[4]
;
de Souza, Sergio Luis Scombatti
[2]
;
Riella, Leonardo
[5]
;
Torroni, Andrea
[6]
;
Jalkh, Ernesto B. Benalcazar
[4, 1]
;
Witek, Lukasz
[1, 7]
;
Lopez, Christopher D.
[8]
;
Zambuzzi, Willian Fernando
[9]
;
Coelho, Paulo G.
[1, 6, 10]
Total Authors: 11
|
| Affiliation: | [1] NYU, Coll Dent, Dept Biomat & Biomimet, New York, NY 10010 - USA
[2] Univ Sao Paulo, Dept Oral & Maxillofacial Surg & Periodont, Sch Dent Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] Univ Ctr State Para, Sch Dent, Dept Periodontol, Belem, PA - Brazil
[4] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont & Periodontol, Bauru, SP - Brazil
[5] Harvard Med Sch, Massachusetts Gen Hosp, Div Nephrol, Boston, MA 02115 - USA
[6] NYU, Hansjorg Wyss Dept Plast Surg, Langone Hlth Sch Med, New York, NY - USA
[7] NYU, Dept Biomed Engn, Tandon Sch Engn, Brooklyn, NY - USA
[8] Johns Hopkins Sch Med Baltimore, Dept Plast & Reconstruct Surg, Baltimore, MD - USA
[9] UNESP Sao Paulo State Univ, Dept Chem & Biol Sci, Bioscience Inst IBB, Botucatu, SP - Brazil
[10] NYU, Dept Mech & Aerosp Engn, Tandon Sch Engn, Brooklyn, NY - USA
Total Affiliations: 10
|
| Document type: | Review article |
| Source: | TRENDS IN ENDOCRINOLOGY AND METABOLISM; v. 31, n. 8, p. 596-610, AUG 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Literature has reported that up to 50% of dental implants may be affected by peri-implantitis, a bacteria-induced chronic inflammatory process, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progressive bone loss around implants. Current evidence points toward an increased risk for the development of peri-implantitis in both obesity/metabolic syndrome (MetS) and diabetes mellitus (DM) conditions relative to the healthy population. Currently, there is no effective treatment for peri-implantitis and the 50% prevalence in MetS and DM, along with its predicted increase in the worldwide population, presents a major concern in implant dentistry as hyperglycemic conditions are associated with bone-healing impairment; this may be through dysfunction of osteocalcin-induced glucose metabolism. The MetS/DM proinflammatory systemic condition and altered immune/microbiome response affect both catabolic and anabolic events of bone-healing that include increased osteoclastogenesis and compromised osteoblast activity, which could be explained by the dysfunction of insulin receptor that led to activation of signals related with osteoblast differentiation. Furthermore, chronic hyperglycemia along with associated micro- and macro-vascular ailments leads to delayed/impaired wound healing due to activation of pathways that are particularly important in initiating events linked to inflammation, oxidative stress, and cell apoptosis; this may be through deactivation of AKT/PKB protein, which possesses a pivotal role in drive survival and eNOS signaling. This review presents an overview of the local and systemic mechanisms synergistically affecting bone-healing impairment in MetS/DM individuals, as well as a rationale for hierarchical animal model selection, in an effort to characterize peri-implantitis disease and treatment. (AU) | |
| FAPESP's process: | 12/19078-7 - Development and processing of Al2O3-ZrO2 translucent composite for CAD/CAM monolithic prostheses: the effect of aging on biaxial flexural strength |
| Grantee: | Estevam Augusto Bonfante |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/03072-6 - Experimental 70% Al2O3-30% ZrO2 composites: structural characterization and survival probability before and after aging |
| Grantee: | Ernesto Byron Benalcazar Jalkh |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 19/08693-1 - Experimental glass-infiltrated alumina-zirconia composites: characterization of microstructure, optical and mechanical properties. |
| Grantee: | Edmara Tatiely Pedroso Bergamo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/00452-5 - EXPERIMENTAL 70%Al2O3-30%ZrO2 ZTA COMPOSITES: MECHANICAL, ESTRUCTURAL AND TOPHOGRAPHICAL CHARACTERIZATION |
| Grantee: | Ernesto Byron Benalcazar Jalkh |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 16/18818-8 - Multi-User Equipment approved in grant 2012/19078-7: ElectroPuls E3000 Linear-Torsion All-Electric dynamic test instrument package |
| Grantee: | Estevam Augusto Bonfante |
| Support Opportunities: | Multi-user Equipment Program |