Acute increases in brain-derived neurotrophic factor following high or moderate-intensity exercise is accompanied with better cognition performance in obese adults

Author(s)

Inoue, Daniela Sayuri ^[1] ; Monteiro, Paula Alves ^[1] ; Gerosa-Neto, Jose ^[1] ; Santana, Priscilla Rodrigues ^{[2, 3]} ; Peres, Fernando Pierin ^[4] ; Edwards, Kate M. ^[5] ; Lira, Fabio Santos ^[1]

Affiliation

^[1] State Univ UNESP, Sch Technol & Sci, Dept Phys Educ, Exercise & Immunometab Res Grp, Postgrad Program M, Presidente Prudente, SP - Brazil

^[2] Univ Sao Judas Tadeu, Psychol Dept, Sao Paulo - Brazil

^[3] Fundacao Santo Andre, Sao Paulo - Brazil

^[4] Univ Oeste Paulista, Med Dept, Sao Paulo - Brazil

^[5] Univ Sydney, Fac Hlth Sci, Charles Perkins Ctr, Sydney, NSW - Australia

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 10, n. 1 AUG 10 2020.
• Web of Science Citations: 0

Abstract

The purpose of this study was to test if different intensities of aerobic exercise could influence abdominal fat, isoforms of BDNF and executive function. Twenty obese men (30.0 +/- 5.4 years old; 34.4 +/- 3.5 kg/m(2)) were randomized to moderate-intensity continuous training (MICT, n=10) and high-intensity intermittent training (HIIT, n=10) three times a week for 6 weeks, with isoenergetic energetic expenditure for each exercise session (similar to 300 kcal) between conditions. Abdominal fat was assessed pre- and post-intervention; executive function (Coding subtest from BETA-III non-verbal intelligence test and Stroop Color and Word Test), concentrations of mBDNF and proBDNF were assessed in response to acute exercise pre- and post-intervention. Abdominal fat did not change in either group. There was a significant increase in mBDNF immediately after acute exercise in both groups before and after intervention. proBDNF did not present changes acutely nor after 6 weeks. Executive function presented a main effect of time at pre- and post-intervention time-points Stroop Word and Stroop Color and Coding subtest presented improved performance from pre- to post-acute exercise session, in both groups. In conclusion, executive function improvements and acute exercise session-induced increases in mBDNF concentration were found from pre- to post-exercise intervention similarly between MICT and HIIT in obese men. (AU)

• FAPESP's process: 16/16712-8 - BDNF involvement in the function of lymphocytes of sedentary obese and trained: relationship with cognitive
• Grantee: Fábio Santos de Lira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/22402-9 - "Impact of high intensity interval exercise on cognitive function, morphological changes and systemic imunometabólicas of young people with obesity"
• Grantee: Daniela Sayuri Inoue Yoshimura
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/03947-0 - Effects of heat intervention during physical exercise on BDNF response in pregnancy
• Grantee: Daniela Sayuri Inoue Yoshimura
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate