In vitrosolar protection factor, antioxidant activity, and stability of a topical formulation containing Benitaka grape (Vitis viniferaL.) peel extract

Author(s)

Cefali, Leticia Caramori ^[1] ; Ataide, Janaina Artem ^[2] ; de Oliveria Sousa, Ilza Maria ^[2] ; Figueiredo, Mariana Cecchetto ^[2] ; Tasca Gois Ruiz, Ana Lucia ^{[3, 4]} ; Foglio, Mary Ann ^{[3, 4]} ; Mazzola, Priscila Gava ^{[3, 4]}

Affiliation

^[1] Univ Estadual Campinas, Inst Biol, Grad Program Biosci & Technol Bioact Prod, UNICAMP, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Pharmaceut Sci, Grad Program Pharmaceut Sci, UNICAMP, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, Campinas, SP - Brazil

^[4] Univ Estadual Campinas, UNICAMP, Chem Biol & Agr Pluridisciplinary Res Ctr CPQBA, Paulinia, SP - Brazil

• Document type: Journal article
• Source: NATURAL PRODUCT RESEARCH; v. 34, n. 18, p. 2677-2682, SEP 16 2020.
• Web of Science Citations: 1

Abstract

A flavonoid enriched extract (FE) was obtained from grape peels, andin vitroSPF, antioxidant activity, and effects on cell viability of this extract were tested with the intent to develop a cosmetic product. A formulation was developed with the FE, and the stability of this mixture was evaluated in terms of pH, density, viscosity, and SPF (90-days). FE showed no cytotoxicity to human keratinocytes and anin vitroSPF of 18.56 (UV-spectrophotometry). Further, FE showed a UVA protection factor of 3.17 +/- 0.2, a critical wavelength of 318.0 +/- 0.1 and a UVA/UVB of 0.9. Antioxidant activity assays resulted in 92.08% and 86.85% of activity against DPPH and ABTS (IC50= 296.90 +/- 1.2 mu g/mL and 643.13 +/- 0.9 mu g/mL), respectively. Finally, SPF of formulation with FE was 12.45. Results from thein vitroSPF and product stability tests (especially storage under refrigeration), indicate that FE is a promising compound for use as an innovative sunscreen formulation. (AU)

• FAPESP's process: 15/25533-7 - DEVELOPMENT AND EVALUATION OF A FLAVONOID ENRICHED EMULSION WITH SUN PROTECTION FACTOR
• Grantee: Leticia Caramori Cefali
• Support Opportunities: Scholarships in Brazil - Doctorate