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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interleukin-1 receptor-induced PGE(2) production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation

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Author(s):
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Reis, Mouzarllem B. [1, 2, 3] ; Rodrigues, Fernanda L. [4, 5] ; Lautherbach, Natalia [6, 4] ; Kanashiro, Alexandre [7] ; Sorgi, Carlos A. [8, 1] ; Meirelles, Alyne F. G. [1] ; Silva, Carlos A. A. [4] ; Zoccal, Karina F. [9] ; Souza, Camila O. S. [1, 2] ; Ramos, Simone G. [10] ; Matsuno, Alessandra K. [11] ; Rocha, Lenaldo B. [12] ; Salgado, Helio C. [4] ; Navegantes, Luiz C. C. [4] ; Kettelhut, Isis C. [4] ; Cupo, Palmira [11] ; Gardinassi, Luiz G. [13, 1, 2] ; Faccioli, Lucia H. [1, 2]
Total Authors: 18
Affiliation:
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[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil
[2] Fac Med Ribeirao Preto, Programa Posgrad Imunol Basica & Aplicada, Sao Paulo - Brazil
[3] Ctr Univ Barao Maua Ribeirao Preto, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Fisiol, Sao Paulo - Brazil
[5] Univ Fed Mato Grosso do Sul, Fac Med, Campus Tres Lagoas CPTL, Mato Grosso - Brazil
[6] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, Sao Paulo - Brazil
[7] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, Sao Paulo - Brazil
[8] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Sao Paulo - Brazil
[9] Ctr Univ Barao Maua, Ribeirao Preto, SP - Brazil
[10] Fac Med Ribeirao Preto, Dept Patol & Med Legal, Sao Paulo - Brazil
[11] Fac Med Ribeirao Preto, Dept Puericultura & Pediat, Sao Paulo - Brazil
[12] Univ Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, Uberaba, MG - Brazil
[13] Univ Fed Goias, Inst Patol Trop & Saude Publ, Goiania, Go - Brazil
Total Affiliations: 13
Document type: Journal article
Source: NATURE COMMUNICATIONS; v. 11, n. 1 OCT 28 2020.
Web of Science Citations: 2
Abstract

Scorpion envenomation is a leading cause of morbidity and mortality among accidents caused by venomous animals. Major clinical manifestations that precede death after scorpion envenomation include heart failure and pulmonary edema. Here, we demonstrate that cardiac dysfunction and fatal outcomes caused by lethal scorpion envenomation in mice are mediated by a neuro-immune interaction linking IL-1 receptor signaling, prostaglandin E-2,E- and acetylcholine release. IL-1R deficiency, the treatment with a high dose of dexamethasone or blockage of parasympathetic signaling using atropine or vagotomy, abolished heart failure and mortality of envenomed mice. Therefore, we propose the use of dexamethasone administration very early after envenomation, even before antiserum, to inhibit the production of inflammatory mediators and acetylcholine release, and to reduce the risk of death. Cardiac dysfunction is a major complication that precedes death after scorpion envenomation. Here, authors show that heart failure and mortality are caused by excessive acetylcholine release, which requires IL-1R-dependent PGE2 production. Dexamethasone treatment effectively inhibits cardiac dysfunction and mortality. (AU)

FAPESP's process: 15/21976-1 - Cardiovascular autonomic control in toll-like receptor 9 knockout mice with hypertension induced by angiotensin II.
Grantee:Fernanda Luciano Rodrigues
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/02314-3 - Investigation of cardiac changes that occur in poisoning by Tityus serrulatus scorpion venom
Grantee:Mouzarllem Barros dos Reis
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/07125-6 - New functional aspects of eicosanoids
Grantee:Lúcia Helena Faccioli
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/00658-1 - New functional aspects of eicosanoids
Grantee:Lúcia Helena Faccioli
Support type: Multi-user Equipment Program