Exercise Enhances the Effect of Bariatric Surgery in Markers of Cardiac Autonomic Function

Author(s):Show less -

Gil, Saulo ^{[1, 2, 3]} ; Pecanha, Tiago ^{[1, 2, 3]} ; Dantas, Wagner S. ^{[1, 2, 3, 4]} ; Murai, Igor Hisashi ^{[1, 2, 3]} ; Abujabra Merege-Filho, Carlos Alberto ^{[1, 2, 3]} ; de Sa-Pinto, Ana Lucia ^[5] ; Rodrigues Pereira, Rosa Maria ^[5] ; de Cleva, Roberto ^[6] ; Santo, Marco Aurelio ^[6] ; Nunes Rezende, Diego Augusto ^{[1, 2, 3]} ; Kirwan, John P. ^[4] ; Gualano, Bruno ^{[1, 2, 3, 5]} ; Roschel, Hamilton ^{[1, 2, 3, 5]}

Affiliation

^[1] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Lab Assessment & Conditioning Rheumatol, Sao Paulo - Brazil

^[4] Louisiana State Univ, Integrated Physiol & Mol Med Lab, Pennington Biomed Res Ctr, Baton Rouge, LA 70803 - USA

^[5] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med FMUSP, Rheumatol Div, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Sch Med, Dept Digest Surg, Sao Paulo - Brazil

• Document type: Journal article
• Source: OBESITY SURGERY; v. 31, n. 3 OCT 2020.
• Web of Science Citations: 0

Abstract

Background Bariatric surgery improves cardiovascular health, which might be partly ascribed to beneficial alterations in the autonomic nervous system. However, it is currently unknown whether benefits from surgery on cardiac autonomic regulation in post-bariatric patients can be further improved by adjuvant therapies, namely exercise. We investigated the effects of a 6-month exercise training program on cardiac autonomic responses in women undergoing bariatric surgery. Methods Sixty-two women eligible for bariatric surgery were randomly allocated to either standard of care (control) or an exercise training intervention. At baseline (PRE) and 3 (POST3) and 9 (POST9) months after surgery, we assessed chronotropic response to exercise (CR%; i.e., percentage change in heart rate from rest to peak exercise) and heart rate recovery (HRR30s, HRR60s, and HRR120s; i.e., decay of heart rate at 30, 60, and 120 s post exercise) after a maximal exercise test. Results Between-group absolute changes revealed higher CR% (Delta = 8.56%, CI95% 0.22-19.90, P = 0.04), HRR30s (Delta = 12.98 beat/min, CI95% 4.29-21.67, P = 0.01), HRR60s (Delta = 22.95 beat/min, CI95% 11.72-34.18, P = 0.01), and HRR120s (Delta = 34.54 beat/min, CI95% 19.91-49.17, P < 0.01) in the exercised vs. non-exercised group. Conclusions Our findings demonstrate that exercise training enhanced the benefits of bariatric surgery on cardiac autonomic regulation. These results highlight the relevance of exercise training as a treatment for post-bariatric patients, ensuring optimal cardiovascular outcomes. (AU)

• FAPESP's process: 16/10993-5 - Effects of exercise training in patients undergoing bariatric surgery: a randomized and clinical trial
• Grantee: Hamilton Augusto Roschel da Silva
• Support Opportunities: Regular Research Grants