Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Miniaturization of liquid chromatography coupled to mass spectrometry. 3. Achievements on chip-based LC-MS devices

Full text
Vargas Medina, Deyber Arley [1] ; Soares Maciel, Edvaldo Vasconcelos [1] ; Lancas, Fernando Mauro [1]
Total Authors: 3
[1] Univ Sao Paulo, Inst Chem Sao Carlos IQSC, Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Review article
Web of Science Citations: 0

Nowadays, miniaturized liquid chromatography (LC) coupled to mass spectrometry is a leading analytical technique in several modern research areas. Its applications will keep in constant spreading, and new and miniaturized instrumental advances will continue to be necessary for the coming years. In this way, chip-based LC-MS technology is one of the most efficient strategies to i) address the extra column band broadening challenges of the capillary/nanoscale, and ii) provide portability, lower-cost and user-friendly character to the miniaturized LC-MS systems. Several commercial chip-based LCeMS are available, because of the notable developments in the manufacturing of the analytical chips throughout the last decades. Since the emerging of the first instruments based on MEMS LC-MS (microelectromechanical systems), diverse microfabrication technologies have been reported to engrave and model a wide gamma of materials and substrates. Within such a context, many strategies to on-chip fully-integration of the solvent delivering systems, injectors, chromatographic media, mass spectrometry interfaces, ionization sources, and mass analyzers have been explored and its feasibility demonstrated. Herein, we provide a comprehensive overview of the major chip technology developments, their state-of-art, and a consistent survey of the recent literature on it. Finally, a description about the most diverse applications of the fully integrated chip-based LC-MS platforms is summarized. In this case, showing remarkable examples using mono and bidirectional systems to the analysis of macro- and small molecules of biochemical, biological, pharmaceutical, clinical, forensic, environmental, foodstuff and quality control interest. (C) 2020 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 19/22724-7 - Novel instrumental approaches for automated and miniaturized analytical methods for the detection of organic compounds by liquid chromatography coupled to mass spectrometry
Grantee:Deyber Arley Vargas Medina
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/03765-0 - Development of an automated solid-phase microextraction based on an arrangement with microsyringes packed sorbent for the simultaneous preparation of multiple samples
Grantee:Deyber Arley Vargas Medina
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/15462-5 - Employment of graphene as sorbent in miniaturized sample preparation techniques.
Grantee:Bruno Henrique Fumes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/02147-0 - Single drop chromatography and its coupling to mass spectrometry: instrumental strategies, development of materials, automation and analytical applications
Grantee:Fernando Mauro Lanças
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/07347-9 - Development of novel materials and devices for miniaturized sample preparation techniques in the area of food safety
Grantee:Fernando Mauro Lanças
Support type: Regular Research Grants