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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues

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Author(s):
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da Rocha, Alisson L. [1] ; Pinto, Ana P. [1] ; Morais, Gustavo P. [1] ; Marafon, Bruno B. [2] ; Rovina, Rafael L. [2] ; Veras, Allice S. C. [3] ; Teixeira, Giovana R. [3, 4] ; Pauli, Jose R. [5] ; de Moura, Leandro P. [5] ; Cintra, Dennys E. [5] ; Ropelle, Eduardo R. [5] ; Rivas, Donato A. [6] ; da Silva, Adelino S. R. [2, 1]
Total Authors: 13
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, BR-14040900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14040900 Ribeirao Preto, SP - Brazil
[3] Sao Paulo State Univ UNESP, Postgrad Program Movement Sci, BR-19060900 Presidente Prudente, SP - Brazil
[4] State Univ Sao Paulo UNESP, Dept Phys Educ, BR-19060900 Presidente Prudente, SP - Brazil
[5] Univ Campinas UNICAMP, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, BR-13484350 Limeira, SP - Brazil
[6] Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA 02111 - USA
Total Affiliations: 6
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 21, n. 22 NOV 2020.
Web of Science Citations: 0
Abstract

The protective effects of chronic moderate exercise-mediated autophagy include the prevention and treatment of several diseases and the extension of lifespan. In addition, physical exercise may impair cellular structures, requiring the action of the autophagy mechanism for clearance and renovation of damaged cellular components. For the first time, we investigated the adaptations on basal autophagy flux in vivo in mice's liver, heart, and skeletal muscle tissues submitted to four different chronic exercise models: endurance, resistance, concurrent, and overtraining. Measuring the autophagy flux in vivo is crucial to access the functionality of the autophagy pathway since changes in this pathway can occur in more than five steps. Moreover, the responses of metabolic, performance, and functional parameters, as well as genes and proteins related to the autophagy pathway, were addressed. In summary, the regular exercise models exhibited normal/enhanced adaptations with reduced autophagy-related proteins in all tissues. On the other hand, the overtrained group presented higher expression of Sqstm1 and Bnip3 with negative morphological and physical performance adaptations for the liver and heart, respectively. The groups showed different adaptions in autophagy flux in skeletal muscle, suggesting the activation or inhibition of basal autophagy may not always be related to improvement or impairment of performance. (AU)

FAPESP's process: 17/17646-1 - Circulating microRNA as novel predictors of skeletal muscle anabolic response in aged humans
Grantee:Adelino Sanchez Ramos da Silva
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 17/19869-8 - Molecular mechanisms related to increased hepatic fat content in response to excessive physical exercise
Grantee:Ana Paula Pinto
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/00855-2 - Sarcopenia, nutrition, and physical activity
Grantee:Adelino Sanchez Ramos da Silva
Support Opportunities: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 17/09038-1 - EFFECTS OF REGULAR PHYSICAL EXERCISE AND OVERTRAINING ON THE BEHAVIOR OF THE AUTOPHAGIC PATHWAY IN DIFFERENT TISSUES OF MICE.
Grantee:Adelino Sanchez Ramos da Silva
Support Opportunities: Regular Research Grants
FAPESP's process: 17/12765-2 - Emerging role of rev-erb-alpha in molecular adaptations to different physical exercise models
Grantee:Alisson Luiz da Rocha
Support Opportunities: Scholarships in Brazil - Doctorate