| Full text | |
| Author(s): |
do Nascimento, Raissa Sansoni
[1]
;
Pedrosa, Lucas de Freitas
[1]
;
Diethelm, Luiza Tamie Hirata
[1]
;
Souza, Thales
[1]
;
Shiga, Tania M.
[1]
;
Fabi, Jao Paulo
[2, 1, 3]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Dept Food Sci & Expt Nutr, Sch Pharmaceut Sci, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Food & Nutr Res Ctr NAPAN, Sao Paulo, SP - Brazil
[3] Sao Paulo Res Fdn, Food Res Ctr FoRC, CEPID FAPESP Res Innovat & Disseminat Ctr, Sao Paulo, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Food Research International; v. 137, NOV 2020. |
| Web of Science Citations: | 0 |
| Abstract | |
Fruits are a prime source of nutrients, bioactive compounds, and dietary fibers. Some products available on the Brazilian market use fruit by-products and claim to have useful effects on human health due to their dietary fiber content. The study aimed to extract and purify the total (28-47 w/w yield) and soluble dietary fiber (4-7 w/w yield) from jaboticaba, papaya, and plum commercial flours sold in Brazil and to study the in vitro biological effects of the fractions. The purified water-soluble fractions consisted mainly of pectin-derived oligosaccharides (5-15 KDa molecular weight) with a negligible content of polyphenols, protein, ashes, and starch. Jaboticaba sample was 95% galacturonic acid while plum and papaya samples were 40% galacturonic acid and 40% galactose (mol%), approximately. The samples were tested for recombinant human galectin-3 inhibition and changes in the cell viability of human colorectal cancer cells. Only the jaboticaba sample inhibited galectin-3 and decreased HCT116 cell viability after 48 h of treatment (p <= 0.01) while the plum sample decreased the cell viability after 24 h treatment (p <= 0.05). The results obtained in this study demonstrate the relationship between the structure of the soluble fibers extracted from jaboticaba flour and the possible beneficial effects of their consumption. (AU) | |
| FAPESP's process: | 13/07914-8 - FoRC - Food Research Center |
| Grantee: | Bernadette Dora Gombossy de Melo Franco |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 12/23970-2 - BIOLOGICAL CHANGES OF PAPAYA PECTINS WITH POSSIBLE BENEFITS TO HUMAN HEALTH |
| Grantee: | Joao Paulo Fabi |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 19/11816-8 - EFFECT OF PAPAYA MODIFIED FIBERS ON THREE-DIMENSIONAL CO-CULTURE OF HUMAN COLON CANCER CELLS AND ON IN VIVO MODEL OF RATS WITH CHEMICALLY INDUCED COLON CARCINOGENESIS |
| Grantee: | Joao Paulo Fabi |
| Support Opportunities: | Regular Research Grants |