Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Study of treatment with hyaluronic acid combined with platelet rich plasma in the in vivo regeneration of defects in articular discs of temporomandibular joint

Full text
Author(s):
El Abras Ankha, Milagros del Valle [1] ; do Prado, Renata Falchete [2] ; Barros Lima, Vinicius de Almeida [1] ; Carvalho, Yasmin Rodarte [1] ; Reis de Vasconcellos, Luana Marotta [1]
Total Authors: 5
Affiliation:
[1] Sao Paulo State Univ, UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, Ave Eng Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
[2] Sao Paulo State Univ, UNESP, Inst Sci & Technol, Dept Dent Mat & Prosthesis, Ave Eng Francisco Jose Longo 777, BR-12245000 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY; v. 32, n. 6, p. 425-440, NOV 2020.
Web of Science Citations: 0
Abstract

The aim of this study was to evaluate the in vivo repair using an experimental model of osteoarthritis of the temporomandibular joint in rabbits, treated with hyaluronic acid (HA), isolated or combined with platelet rich plasma (PRP). Forty New Zealand rabbits were divided into 4 groups: G1 - normal TMJ, G2 - lesion / untreated, G3 - lesion / HA, and G4 - lesion / PRP + HA. The disc and the condyle were evaluated using radiographies, macro and microscopic analysis through routine histotechnique, Picrosirius red staining and immunohistochemistry. The results were evaluated by descriptive and inferential statistics. Macroscopically, the disc in the treated groups presented, in most of the specimens, partial or total filling of the defect. Histological analysis confirmed the presence of mineralized material, near and distant perforation, as well as decreased cellularity and fibrosis. The collagen I was demonstrated in higher amounts when compared to type III collagen, independently of the group and period evaluated; in the condyle, G3 and G4 presented significant higher percentage of type I collagen, than G2. In conclusion, the groups that were treated with HA and PRP combined with HA presented no significant differences in microscopic pattern. The macroscopic finding that in some samples in HA treated group and one sample in PRP + HA group presented complete filling of the perforation let us to conclude that new experiments adding more sensitive methods may clear the influence of these treatments in reduce the damage in the osteochondral surface related the lesioned disc. (AU)

FAPESP's process: 16/23446-2 - Regeneration of articular disc defects and osteochondral surface caused by osteoarthritis in the temporomandibular joint
Grantee:Luana Marotta Reis de Vasconcellos
Support Opportunities: Regular Research Grants
FAPESP's process: 18/13473-8 - Regeneration of defects in the TMJ joint disc, treated with hyaluronic acid hydrogel associated with mesenchymal stem cells, with chondrogenic differentiation
Grantee:Vinícius Almeida de Barros Lima
Support Opportunities: Scholarships in Brazil - Scientific Initiation