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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Duffy blood group system and ocular toxoplasmosis

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Costa Ferreira, Ana Iara [1, 2] ; Brandao de Mattos, Cinara Cassia [1] ; Frederico, Fabio Batista [3] ; Bernardo, Cassia Rubia [2] ; de Almeida Junior, Gildasio Castelo [3] ; Siqueira, Rubens Camargo [1] ; Meira-Strejevitch, Cristina Silva [4] ; Pereira-Chioccola, Vera Lucia [4] ; de Mattos, Luiz Carlos [1]
Total Authors: 9
[1] Fac Med Sao Jose Rio Preto, Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Fed Roraima, Boa Vista, Parana - Brazil
[3] Fundacao Fac Reg Med Sao Jose Do Rio Preto, Ophthalmol Outpatient Clin, Sao Jose Do Rio Preto, SP - Brazil
[4] Adolpho Lutz Inst, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Duffy blood group phenotypes {[}Fy(a + b-), Fy(a-b+), Fy(a + b+), Fy(a-b-)], characterized by the expression of Fy(a), and Fy(b) antigens, are present in red blood cells. Therefore, we hypothesize that the non-hematopoietic expression of these antigens might influence cell invasion by T. gondii. 576 consecutive patients from both genders were enrolled. The presumed OT clinical diagnosis was performed. Duffy phenotyping was performed by hemagglutination in gel columns and for the correct molecular characterization Fy(a-b-) phenotype, using PCR-RFLP. Anti -T. gondii IgG antibodies were detected by ELISA. Chi-square, Fisher's exact tests were used to compare the proportions. OT was present in 22.9% (n = 132) and absent in 77.1% (n = 444) of patients. The frequencies of anti -T. gondii IgG antibodies were higher in OT (127/132, 96.2%) than those without this disease (321/444, 72.3%) (p < .0001). None of the Duffy antigens or phenotypes were associated with T. gondii infection (chi 2: 2.222, GL: 3, p = .5276) as well as the risk of OT (chi 2: 0.771, GL: 3, p = .8566). Duffy blood group system phenotypes and their antigens do not constitute risk factors for infection by T. gondii infection and the development of OT. (AU)

FAPESP's process: 09/17540-2 - Histo blood groups like risk factor for ocular toxoplasmosis
Grantee:Luiz Carlos de Mattos
Support type: Regular Research Grants
FAPESP's process: 15/17226-7 - Biomarkers in ocular diseases
Grantee:Gildásio Castello de Almeida Júnior
Support type: Regular Research Grants
FAPESP's process: 12/05580-2 - Immunogenetics markers in Chagas disease
Grantee:Cássia Rubia Bernardo
Support type: Scholarships in Brazil - Master
FAPESP's process: 09/09168-6 - Toxoplasma gondii excreted-secreted antigens (ESA): Analysis of infected host immune response
Grantee:Cristina da Silva Meira Strejevitch
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 11/13939-8 - Study of a group of fungal and parasitic infections aiming the improvement of techniques of characterization and immune-molecular diagnosis
Grantee:Vera Lúcia Pereira Chioccola
Support type: Regular Research Grants