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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Are Silver Nanoparticles Useful for Treating Second-Degree Burns? An Experimental Study in Rats

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Author(s):
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Neto Moreno, Debora Antunes [1] ; Saladin, Mirela Santos [2] ; Marques Viroel, Fabia Judice [1] ; Juste Dini, Murilo Melo [1] ; Pickier, Thaisa Borim [3] ; Amaral Filho, Jorge [2] ; dos Santos, Carolina Alves [1] ; Hanai-Yoshida, Valquiria Miwa [4] ; Grotto, Denise [1, 4] ; Gerenutti, Marli [5] ; Hyslop, Stephen [6] ; Oshima-Franco, Yoko [1]
Total Authors: 12
Affiliation:
[1] Univ Sorocaba UNISO, Grad Program Pharmaceut Sci, Sorocaba, SP - Brazil
[2] Univ Sorocaba UNISO, Vet Med Grad Course, Sorocaba, SP - Brazil
[3] Univ Sorocaba UNISO, Lab Toxicol Res Lapetox, Sorocaba, SP - Brazil
[4] Univ Sorocaba UNISO, Grad Program Environm & Technol Proc, Sorocaba, SP - Brazil
[5] Pontifical Catholic Univ Sao Paulo PUC SP, Sch Med Sci, Sorocaba, SP - Brazil
[6] State Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, Campinas, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: ADVANCED PHARMACEUTICAL BULLETIN; v. 11, n. 1, p. 130-136, 2021.
Web of Science Citations: 0
Abstract

Purpose: In this work, the potential usefulness of silver nanoparticles (AgNPs) for treating burn wounds was examined. Methods: Second-degree burns were induced in male Wistar rats by touching the skin with a heated (70 degrees C) metallic device for 10 s, after which the animals were randomly allocated to one of two groups: control (n=8, treated with sterile saline) and experimental (n=8, treated with AgNPs, 0.081 mg/mL; 50 mu L applied to the burn surface). Seven, 14, 21 and 28 days after lesion induction two rats from each group were killed and blood samples were collected for a complete blood count and to assess oxidative stress. The livers were examined macroscopically and skin samples were collected for histological analysis. Results: Macroscopically, wound healing and skin remodeling in the experimental group were similar to the saline-treated rats. Likewise, there were no significant differences in the histological parameters between the two groups. However, treatment with AgNPs caused a persistent reduction in white blood cell (WBC) counts throughout the experiment, whereas platelet counts increased on days 7 and 28 but decreased on days 14 and 21; there was also an increase in the blood concentration of reduced glutathione on day 7 followed by a decrease on days 21 and 28. There were no significant changes in blood glutathione peroxidase (GSH-Px) and catalase (CAT) activities or in the serum concentration of thiobarbituric acid reactive substances. Conclusion: The findings of this study raise questions about the potential transitory effects of AgNPs based on the changes in WBC and platelet counts, blood glutathione concentrations and macroscopic hepatic alterations. (AU)

FAPESP's process: 12/08271-0 - IDENTIFICATION AND PHARMACODYNAMIC OF NEUROFACILITATING FRACTIONS OF Casearia sylvestris SW. AT THE NEUROMUSCULAR JUNCTION
Grantee:Yoko Oshima Franco
Support Opportunities: Regular Research Grants
FAPESP's process: 15/01420-9 - Development and efficacy evaluation (in vitro and in vivo) of a hemoperfuser cartridge for the antiophidian treatment
Grantee:Yoko Oshima Franco
Support Opportunities: Regular Research Grants
FAPESP's process: 08/11005-5 - Dipteryx alata Vogel: antiophidian action and toxicity
Grantee:Yoko Oshima Franco
Support Opportunities: Scholarships abroad - Research