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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The relevance of anti-Jo-1 autoantibodies in patients with definite dermatomyositis

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Author(s):
Vanessa Posener de Andrade [1] ; Fernando Henrique Carlos De Souza [2] ; Gustavo Luiz Behrens Pinto [3] ; Samuel Katsuyuki Shinjo
Total Authors: 4
Affiliation:
[1] Universidade de Sao Paulo. Faculdade de Medicina. Division of Rheumatology - Brasil
[2] Universidade de Sao Paulo. Faculdade de Medicina. Division of Rheumatology - Brasil
[3] Universidade de Sao Paulo. Faculdade de Medicina. Division of Rheumatology - Brasil
Total Affiliations: 4
Document type: Journal article
Source: ADVANCES IN RHEUMATOLOGY; v. 61, 2021-03-01.
Abstract

Abstract Background: To assess the prevalence and clinical relevance of anti-Jo-1 autoantibodies in a representative sample of patients with definite dermatomyositis (DM). Methods: This retrospective cohort study took place from 2005 to 2020 and assessed 118 adult patients from a tertiary center who were diagnosed with definite DM. A commercial kit was used to detect anti-Jo-1 autoantibodies. Results: The presence of anti-Jo-1 autoantibodies was observed in 10 out of 118 (8.5%) patients with definite DM. The following variables were comparable between individuals with and without anti-Jo-1 autoantibodies: age at diagnosis, sex, ethnicity, disease duration, follow-up period, recurrence rate, complete clinical response, death rate, and cancer incidence. There was no difference in clinical features between groups, except for an increased prevalence of “mechanic's hands,” joint involvement, and lung disease, as well as a reduced occurrence of skin findings in patients positive for anti-Jo-1 autoantibodies. No anti-Jo-1-positive patients went into remission; they required greater use of glucocorticoids and immunosuppressive drugs. Conclusions: Anti-Jo-1 positivity was found in 8.5% of patients with definite DM. This autoantibody was associated with an antisynthetase syndrome phenotype and might predict clinical outcomes in patients with definite DM. (AU)

FAPESP's process: 14/09079-1 - Impact of corticosteroids in the inflammatory process of muscle biopsies of dermatomyositis and polymyositis
Grantee:Samuel Katsuyuki Shinjo
Support Opportunities: Regular Research Grants