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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Taurine treatment reverses protein malnutrition-induced endothelial dysfunction of the pancreatic vasculature: The role of hydrogen sulfide

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Guizoni, Daniele M. [1] ; Freitas, Israelle N. [1] ; Victorio, Jamaira A. [1] ; Possebom, Isabela R. [1] ; Araujo, Thiago R. [2] ; Carneiro, Everardo M. [2] ; Davel, Ana P. [1]
Total Authors: 7
[1] Univ Campinas UNICAMP, Dept Struct & Funct Biol, Inst Biol, Lab Vasc Biol, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Dept Struct & Funct Biol, Inst Biol, Obes & Comorbid Res Ctr OCRC, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 0

Background: Protein malnutrition in childhood predisposes individuals to vascular and pancreatic endocrine dysfunction, thus increasing the risk of diabetes and hypertension. Because taurine may reduce cardiometabolic risk, we hypothesized that taurine treatment has a beneficial effect on the pancreatic vasculature during protein restriction. Methods and results: Weaned mice were fed a normal or a low-protein diet and were treated with or without taurine for 3 months. The lieno-pancreatic artery (LPA) from low-protein diet-treated mice exhibited impaired endothelium dependent relaxation to acetylcholine that was associated with decreased endothelium-derived hyperpolarization (EDH), hydrogen sulfide (H2S) production, and H2S-synthesizing CBS expression and impaired vasorelaxation to an H2S-donor, NaHS. These changes were prevented by taurine treatment. We compared the effects of taurine with the effects of the direct vasodilator hydralazine and found that both normalized blood pressure and the endothelial vasodilator function of the LPA in the mice fed a protein-restricted diet. However, only taurine restored the CBS expression in the LPA and insulin secretion in response to high glucose. The LPA supplies the pancreas and shares morphometry with the mesenteric resistance artery (MRA). However, in the MRA, low-protein diet-induced endothelial dysfunction is driven by impaired NOS-derived NO with no changes in H2S signaling. Conclusions: The results suggest that taurine protects against protein malnutrition-induced endothelial dysfunction in the LPA by upregulating the CBS-H2S pathway. Considering the importance of the pancreatic vasculature for endocrine islet activity, taurine may be a potential therapy for the vascular and metabolic dysfunction associated with malnutrition and comorbidities. (C) 2021 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 16/14461-8 - In vivo and in vitro endothelial effects of taurine in protein restriction
Grantee:Daniele Mendes Guizoni
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/01717-9 - Investigation of the insulinotropic, insulinomimetic and endothelial actions of taurine in cells/tissues submitted to an in vitro amino acid restriction: an integrated and multifocal approach
Grantee:Everardo Magalhães Carneiro
Support type: Research Projects - Thematic Grants