Insights into the Antimicrobial Activity of Hydrated Cobaltmolybdate Doped with Copper

Author(s):Show less -

Silva, Layane A. L. ^[1] ; Silva, Andre A. L. ^[2] ; Rios, Maria A. S. ^[3] ; Brito, Manoel P. ^[4] ; Araujo, Alyne R. ^[4] ; Silva, Durcilene A. ^[4] ; Pena-Garcia, Ramon R. ^{[1, 5]} ; Silva-Filho, Edson C. ^[1] ; Magalhaes, Janildo L. ^[2] ; Matos, Jose M. E. ^[1] ; Osajima, Josy A. ^[1] ; Triboni, Eduardo R. ^[6]

Affiliation

^[1] Univ Fed Piaui, Interdisciplinary Lab Adv Mat, BR-64049550 Teresina - Brazil

^[2] Univ Fed Piaui, Supramol Self Assembly Lab, BR-64049550 Teresina - Brazil

^[3] Univ Fed Ceara, Grp Technol Innovat & Chem Specialties, BR-60455760 Fortaleza, Ceara - Brazil

^[4] Fed Univ Delta Parnaiba, Biodivers & Biotechnol Res Ctr, BR-64202020 Parnaiba - Brazil

^[5] Univ Fed Rural Pernambuco, Acad Unit Cabo de Santo Agostinho, BR-52171900 Cabo De Santo Agostinho - Brazil

^[6] Univ Sao Paulo, Nanotechnol & Proc Engn NEP, BR-12602810 Lorena - Brazil

• Document type: Journal article
• Source: Molecules; v. 26, n. 5 MAR 2021.
• Web of Science Citations: 0

Abstract

Molybdates are biocidal materials that can be useful in coating surfaces that are susceptible to contamination and the spread of microorganisms. The aim of this work was to investigate the effects of copper doping of hydrated cobalt molybdate, synthesized by the co-precipitation method, on its antibacterial activity and to elucidate the structural and morphological changes caused by the dopant in the material. The synthesized materials were characterized by PXRD, Fourier Transformed Infrared (FTIR), thermogravimetric analysis/differential scanning calorimetry (TG/DSC), and SEM-Energy Dispersive Spectroscopy (SEM-EDS). The antibacterial response of the materials was verified using the Minimum Inhibitory Concentration (MIC) employing the broth microdilution method. The size of the CoMoO4 center dot 1.03H(2)O microparticles gradually increased as the percentage of copper increased, decreasing the energy that is needed to promote the transition from the hydrated to the beta phase and changing the color of material. CoMoO4 center dot 1.03H(2)O obtained better bactericidal performance against the tested strains of Staphylococcus aureus (gram-positive) than Escherichia coli (gram-negative). However, an interesting point was that the use of copper as a doping agent for hydrated cobalt molybdate caused an increase of MIC value in the presence of E. coli and S. aureus strains. The study demonstrates the need for caution in the use of copper as a doping material in biocidal matrices, such as cobalt molybdate. (AU)

• FAPESP's process: 17/13839-0 - Organic and inorganic systems for obtaining of meso and nanostructures
• Grantee: Eduardo Rezende Triboni
• Support Opportunities: Regular Research Grants