Pre-pregnancy BMI is associated with offspring body composition in adulthood before adiposity-related disorders: a retrospective cohort

Author(s)

Eshriqui, Ilana ^[1] ; Valente, Angelica Marques Martins ^[2] ; Folchetti, Luciana Dias ^[3] ; de Almeida-Pititto, Bianca ^[4] ; Ferreira, Sandra Roberta G. ^[5]

Affiliation

^[1] Univ Sao Paulo, Sch Publ Hlth, Grad Program Publ Hlth Nutr, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Publ Hlth, Grad Program Epidemiol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Prevent Med, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Av Dr Arnaldo 715, BR-01246904 Sao Paulo - Brazil

• Document type: Journal article
• Source: PUBLIC HEALTH NUTRITION; v. 24, n. 6, p. 1296-1303, APR 2021.
• Web of Science Citations: 1

Abstract

Objective: To investigate the association between maternal pre-pregnancy BMI and offspring body composition in adulthood. Design: Retrospective cohort. Undergraduates of nutrition or nutritionists were recruited at the baseline of the Nutritionists' Health Study between 2014 and 2017. Maternal pre-pregnancy BMI and current life aspects were self-reported through online questionnaires. Three body compartments were dual-energy x-ray absorptiometry-determined. The following variables were obtained: body fat (%), fat mass index (FMI) (kg/m(2)), android-to-gynoid fat ratio, visceral adipose tissue (VAT) (cm(3)), appendicular skeletal muscle mass index (ASMI) (kg/m(2)), total bone and femur mineral content (g) and density (g/cm(2)). Linear regression adjusted according to directed acyclic graphs recommendation was performed. Setting: Sao Paulo, Brazil. Participants: Healthy non-pregnant women (aged 20-45 years) (n 150). Results: Median age and BMI were 22 years (IQR = 20, 29) and 22 center dot 3 kg/m(2) (IQR = 20 center dot 4, 25 center dot 3), respectively. Pre-pregnancy BMI >= 25 kg/m(2) was reported by 14 center dot 7 % of mothers. In fully adjusted models, maternal pre-pregnancy BMI was associated with their daughters' body fat % (beta = 0 center dot 31; 95 % CI 0 center dot 0004, 0 center dot 63), FMI (beta = 0 center dot 17; 95 % CI 0 center dot 03, 0 center dot 30), android-to-gynoid ratio (beta = 0 center dot 01; 95 % CI 0 center dot 004, 0 center dot 02) and VAT (beta = 0 center dot 09; 95 % CI 0 center dot 02, 0 center dot 16), but not with total bone density (beta = 0 center dot 001; 95 % CI -0 center dot 003, 0 center dot 006) and content (beta = 7 center dot 13; 95 % CI -4 center dot 19, 18 center dot 46). Direct association with ASMI was also detected, but lost statistical significance when participants whose mothers were underweight were excluded. Conclusions: Maternal pre-pregnancy BMI was directly associated with offspring general and visceral adiposity but seems not to be associated with bone mass. Results reinforce importance of avoiding excess of maternal adiposity, as an attempt to break the vicious cycle of obesity transmission. (AU)

• FAPESP's process: 17/13087-8 - Breastfeeding and other early life events and its association with dietary patterns, body composition e cardiometabolic profile during adult life
• Grantee: Ilana Eshriqui Oliveira
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/10045-7 - Interelationship of body composition and early factors in lifespan in the Nutritionist Health Study: modulation by gut microbiota?
• Grantee: Sandra Roberta Gouvea Ferreira Vivolo
• Support Opportunities: Regular Research Grants