| Full text | |
| Author(s): Show less - |
Palmier, Natalia Rangel
[1]
;
Paes Leme, Adriana Franco
[2]
;
De Rossi, Tatiane
[2]
;
Telles, Guilherme Pimentel
[3]
;
Morais-Faria, Karina
[4]
;
Kowalski, Luiz Paulo
[5]
;
Marta, Gustavo Nader
[6, 7]
;
Brandao, Thais Bianca
[4, 8]
;
Arany, Praveen R.
[9]
;
Migliorati, Cesar Augusto
[10]
;
Santos-Silva, Alan Roger
[1]
;
Prado-Ribeiro, Ana Carolina
[4]
Total Authors: 12
|
| Affiliation: | [1] Univ Estadual Campinas, Oral Diag Dept, Piracicaba Dent Sch, Campinas - Brazil
[2] CNPEM, Brazilian Biosci Natl Lab, LNBio, Campinas - Brazil
[3] Univ Campinas UNICAMP, Inst Comp, Campinas - Brazil
[4] ICESP FMUSP, Dent Oncol Serv, Inst Canc Estado Sao Paulo, Sao Paulo - Brazil
[5] Univ Sao Paulo, Cent Inst, Hosp Clin, Med Sch FMUSP, Sao Paulo - Brazil
[6] Hosp Sirio Libanes, Dept Radiat Oncol, Sao Paulo - Brazil
[7] ICESP FMUSP, Dept Radiol & Oncol, Div Radiat Oncol, Inst Canc Estado Sao Paulo, Sao Paulo - Brazil
[8] Hosp Sirio Libanes, Oral Med Dept, Sao Paulo - Brazil
[9] Univ Buffalo, Oral Biol & Biomed Engn, Buffalo, NY - USA
[10] Univ Florida, Coll Dent, Gainesville, FL - USA
Total Affiliations: 10
|
| Document type: | Journal article |
| Source: | SUPPORTIVE CARE IN CANCER; v. 29, n. 6, p. 2939-2946, JUN 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Aims Evaluate the abundance of the selected targets, alpha-1-antitrypsin (A1AT) and macrophage migration inhibitory factor (MIF), and correlate these findings with the risk of developing severe oral mucositis (OM). Materials and methods Head and neck squamous cell carcinoma (HNSCC) patients submitted to radiotherapy (RT) or chemoradiotherapy (CRT) were assessed. OM grade and pain were evaluated daily during treatment. Two protein targets, A1AT and MIF, were evaluated, using selected reaction monitoring-mass spectrometry (SRM-MS), in whole saliva, collected prior to oncologic treatment. The results obtained from the targeted proteomic analysis were correlated with OM clinical outcomes. Results A total of 27 patients were included, of whom 21 (77.8%) had locally advanced disease (clinical stage III or IV). Most patients (70.4%) received CRT. OM grades 2 (40.8%) and 3 (33.3%) were the most prevalent during RT with a mean highest reported OM-related pain of 3.22 through the visual analogue scale (VAS). The abundance of A1AT and MIF correlated significantly with severe (grades 3 or 4,p < 0.02) compared with moderate-low (grades 1 or 2,p < 0.04) OM grade. Conclusions There is a correlation between the abundance of salivary A1AT and MIF and oncologic treatment-induced OM. The correlation of MIF expression with severe OM appears to be compatible with its physiological pro-inflammatory role. These results open up great possibilities for the use of salivary MIF and A1AT levels as prognostic markers for effective therapeutic interventions, such as photobiomodulation therapy, patient-controlled analgesia, or personalized medicaments. (AU) | |
| FAPESP's process: | 18/04657-8 - Salivary protein markers of radiation-related oral toxicites |
| Grantee: | Natália Rangel Palmier |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 15/12431-1 - Verification of saliva proteins candidates for markers in OSCC and its correlation with prognosis |
| Grantee: | Tatiane de Rossi Mazo |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/06138-1 - A prospective study of radiation-induced trismus in patients with oral squamous cell carcinoma |
| Grantee: | Ana Carolina Prado Ribeiro e Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/18402-8 - Evaluation of the direct effects of radiation on the enamel, dentin and dental pulp of head and neck cancer patients |
| Grantee: | Alan Roger dos Santos Silva |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/22862-2 - Impact of age in radiation-induced oral toxicities of young patients with oral cancer |
| Grantee: | Jaqueline de Lima Correia |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 16/07846-0 - Peptidomic analysis of extracelular vesicles originated from cell lines, saliva and plasma from oral squamous cell carcinoma |
| Grantee: | Adriana Franco Paes Leme |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/02233-6 - Oncological safety of the use of intraoral and extraoral photobiomodulation in patients with oral cavity and oropharyngeal squamous cell carcinoma |
| Grantee: | Alan Roger dos Santos Silva |
| Support Opportunities: | Regular Research Grants |