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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis

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Author(s):
Libardi Bertachini, Ana Livia [1, 2] ; Januario, Gabriela Cintra [1, 2] ; Novi, Sergio Luiz [3] ; Mesquita, Rickson Coelho [3] ; Romano Silva, Marco Aurelio [4] ; Queiroz Andrade, Glaucia Manzan [1, 2] ; de Resende, Luciana Macedo [2, 5] ; de Miranda, Debora Marques [1, 6]
Total Authors: 8
Affiliation:
[1] Univ Fed Minas Gerais, Dept Pediat, Belo Horizonte, MG - Brazil
[2] UFMG Univ Fed Minas Gerais, NUPAD Ctr Newborn Screening & Genet Diagnost, Belo Horizonte, MG - Brazil
[3] Univ Estadual Campinas, Gleb Wataghin Inst Phys, Campinas - Brazil
[4] Univ Fed Minas Gerais, Dept Mental Hlth, Belo Horizonte, MG - Brazil
[5] Univ Fed Minas Gerais, Dept Speech & Hearing Therapy, Belo Horizonte, MG - Brazil
[6] Univ Fed Minas Gerais, Ctr Tecnol Med Mol, Ave Prof Alfredo Balena 190, BR-30130100 Belo Horizonte, MG - Brazil
Total Affiliations: 6
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 11, n. 1 MAY 12 2021.
Web of Science Citations: 1
Abstract

Congenital toxoplasmosis (CT) is a known cause of hearing loss directly caused by Toxoplasma gondii. Hearing loss might result from sensory, neural, or sensorineural lesions. Early treated infants rarely develop hearing loss, but retinochoroidal lesions, intracranial calcifications and hydrocephalus are common. In this study, we aimed to evaluate the brain evoked hemodynamic responses of CT and healthy infants during four auditory stimuli: mother infant directed speech, researcher infant directed speech, mother reading and researcher recorded. Children underwent Transitionally Evoked Otoacoustic Emission Auditory Testing and Automated Brainstem Auditory Response tests with normal auditory results, but with a tendency for greater latencies in the CT group compared to the control group. We assessed brain hemodynamics with functional near-infrared spectroscopy (fNIRS) measurements from 61 infants, and we present fNIRS results as frequency maps of activation and deactivation for each stimulus. By evaluating infants in the three first months of life, we observed an individual heterogeneous brain activation pattern in response to all auditory stimuli for both groups. Each channel was activated or deactivated in less than 30% of children for all stimuli. There is a need of prospective studies to evaluate if the neurologic or auditory changes course with compromise of children outcomes. (AU)

FAPESP's process: 16/22990-0 - Assessment of neuroplasticity in the human brain with near-infrared spectroscopy
Grantee:Sergio Luiz Novi Junior
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 19/21962-1 - Investigation of neuroplasticity in the human brain with near-infrared spectroscopy
Grantee:Sergio Luiz Novi Junior
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
Grantee:Fernando Cendes
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC