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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice

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Author(s):
Watanabe, Akio [1, 2] ; de Almeida, Marilia Oliveira [3] ; Deguchi, Yusuke [4] ; Kozuka, Ryuzo [4] ; Arruda, Caroline [3] ; Berretta, Andresa Aparecida [5] ; Bastos, Jairo Kenupp [3] ; Woo, Je-Tae [1, 4] ; Yonezawa, Takayuki [1]
Total Authors: 9
Affiliation:
[1] Chubu Univ, Res Inst Biol Funct, Kasugai, Aichi 4878501 - Japan
[2] Jumonji Univ, Fac Human Life, Dept Food Sci, Saitama 3528510 - Japan
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ave Cafe S-N, BR-14040903 Ribeirao Preto, SP - Brazil
[4] Chubu Univ, Dept Biol Chem, Kasugai, Aichi 4878501 - Japan
[5] APIS FLORA INDL COML LTDA, Lab Res Dev & Innovat, BR-14020670 Ribeirao Preto, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 22, n. 13 JUL 2021.
Web of Science Citations: 0
Abstract

Propolis is a honeybee product with various biological activities, including antidiabetic effects. We previously reported that artepillin C, a prenylated cinnamic acid derivative isolated from Brazilian green propolis, acts as a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand and promotes adipocyte differentiation. In this study, we examined the effect of baccharin, another major component of Brazilian green propolis, on adipocyte differentiation. The treatment of mouse 3T3-L1 preadipocytes with baccharin resulted in increased lipid accumulation, cellular triglyceride levels, glycerol-3-phosphate dehydrogenase activity, and glucose uptake. The mRNA expression levels of PPAR gamma and its target genes were also increased by baccharin treatment. Furthermore, baccharin enhanced PPAR gamma-dependent luciferase activity, suggesting that baccharin promotes adipocyte differentiation via PPAR gamma activation. In diabetic ob/ob mice, intraperitoneal administration of 50 mg/kg baccharin significantly improved blood glucose levels. Our results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus. (AU)

FAPESP's process: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector
Grantee:Jairo Kenupp Bastos
Support Opportunities: Research Projects - Thematic Grants