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| Full text | |
| Author(s): |
de Freitas Martins, Ernane
[1, 2, 3]
;
Pinotti, Luis Francisco
[4]
;
Castro Silva, Cecilia de Carvalho
[5]
;
Rocha, Alexandre Reily
[6]
Total Authors: 4
|
| Affiliation: | [1] CSIC, Catalan Inst Nanosci & Nanotechnol ICN2, Campus UAB, Barcelona 08193 - Spain
[2] BIST, Campus UAB, Barcelona 08193 - Spain
[3] Royal Melbourne Inst Technol RMIT Univ, Sch Engn, Melbourne, Vic 3004 - Australia
[4] Univ Campinas Unicamp, Sch Elect & Comp Engn FEEC, Semicond Instruments & Photon Dept DSIF, BR-13083852 Campinas, SP - Brazil
[5] Univ Prebiteriana Mackenzie, MackGraphe Mackenzie Inst Res Graphene & Nanotech, BR-01302907 Sao Paulo - Brazil
[6] Sao Paulo State Univ UNESP, Inst Fis Teor, BR-01140070 Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Review article |
| Source: | CHEMOSENSORS; v. 9, n. 7 JUL 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Electrochemical immunosensors (EI) have been widely investigated in the last several years. Among them, immunosensors based on low-dimensional materials (LDM) stand out, as they could provide a substantial gain in fabricating point-of-care devices, paving the way for fast, precise, and sensitive diagnosis of numerous severe illnesses. The high surface area available in LDMs makes it possible to immobilize a high density of bioreceptors, improving the sensitivity in biorecognition events between antibodies and antigens. If on the one hand, many works present promising results in using LDMs as a sensing material in EIs, on the other hand, very few of them discuss the fundamental interactions involved at the interfaces. Understanding the fundamental Chemistry and Physics of the interactions between the surface of LDMs and the bioreceptors, and how the operating conditions and biorecognition events affect those interactions, is vital when proposing new devices. Here, we present a review of recent works on EIs, focusing on devices that use LDMs (1D and 2D) as the sensing substrate. To do so, we highlight both experimental and theoretical aspects, bringing to light the fundamental aspects of the main interactions occurring at the interfaces and the operating mechanisms in which the detections are based. (AU) | |
| FAPESP's process: | 17/02317-2 - Interfaces in materials: electronic, magnetic, structural and transport properties |
| Grantee: | Adalberto Fazzio |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 16/01343-7 - ICTP South American Institute for Fundamental Research: a regional center for theoretical physics |
| Grantee: | Nathan Jacob Berkovits |
| Support Opportunities: | Special Projects |