| Full text | |
| Author(s): Show less - |
Gomes, Laura Cordeiro
[1]
;
Sanson, Marina Cordeiro Gomes
[2]
;
Brainin, Philip
[3]
;
de Melo, Maria da Conceicao Vieira
[2]
;
de Souza, Rodrigo Medeiros
[2]
;
Mazaro, Janaina
[4]
;
Lima, Karine Oliveira
[2]
;
Resende, Junia Silva
[2]
;
Vieira, Isabelle Victoria Martins
[2]
;
Mesquita, Edinilson da Silva
[2]
;
Matos, Luan Oliveira
[2]
;
Dutra, Isabelle Caroline Silva
[2]
;
Palmisano, Giuseppe
[5]
;
Wrenger, Carsten
[5]
;
Marinho, Claudio Romero Farias
[5]
;
da Silva, Rita do Socorro Uchoa
[1]
Total Authors: 16
|
| Affiliation: | [1] Univ Fed Acre, Hlth & Sport Sci Ctr, Rio Branco, Acre - Brazil
[2] Univ Fed Acre, Multidisciplinary Ctr, Cruzeiro Do Sul, Acre - Brazil
[3] Herlev Gentofte Univ Hosp, Hellerup - Denmark
[4] Lab Publ Hlth Acre, Cruzeiro Do Sul, Acre - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | PLoS One; v. 16, n. 7 2021. |
| Web of Science Citations: | 0 |
| Abstract | |
Background Despite completion of the vaccine schedule for hepatitis B virus (HBV), children may display levels of HBV surface antibodies (anti-HBs) that are considered inadequate for sufficient protection (<10 IU/L). Aims Our aim was to investigate if age and gap time between HBV vaccine doses may negatively affect the levels of anti-HBs in children, and if these relationships are modified by sex. Methods In a high-endemic HBV region of the western Brazilian Amazon we enrolled children who had completed the HBV vaccine schedule. All children underwent analysis of anti-HBs and a clinical examination. Results We included 522 children (mean age 4.3 +/- 0.8 years; 50% male). Median anti-HBs was 28.4 {[}interquartile range (IQR) 5.4 to 128.6] IU/L and 32% had anti-HBs <10 IU/L. The median gap time from last to preceding dose was 2.4 {[}IQR 2.1 to 3.3] months. Levels of anti-HBs decreased with higher age (-42% per year increase {[}95%CI -56% to -24%], p<0.001), but not with longer gap time (+23% per month increase {[}95%CI -16% to +62%], p = 0.249). After adjusting for relevant confounders, gap time became significant (p = 0.032) and age remained a significant predictor of anti-HBs (p<0.001). Conclusion One third of assessed children displayed anti-HBs <10 IU/L. Levels of anti-HBs decreased with higher age and increased with longer gap time between the last two doses. (AU) | |
| FAPESP's process: | 18/20468-0 - RECRUDESCENCE OF THE MALARIA DURING PREGNANCY: EFFECTS AND MECHANISMS |
| Grantee: | Cláudio Romero Farias Marinho |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/18257-1 - Multi-user equipment approved in grant 14/06863-3: HPLC System configured for analysis of carbohydrates, amino acidis, peptides and glycoproteins. |
| Grantee: | Giuseppe Palmisano |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 18/15549-1 - Post-translational modifications in Chagas disease biological processes and diagnostics: novel methodological approaches and biological applications |
| Grantee: | Giuseppe Palmisano |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 15/26722-8 - Drug Discovery against Human Infectious Diseases |
| Grantee: | Carsten Wrenger |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/06863-3 - Post-Translational Modifications in cancer and parasite infection diagnosis: methodological approaches and biological implications |
| Grantee: | Giuseppe Palmisano |
| Support Opportunities: | Research Grants - Young Investigators Grants |