Levels of hepatitis B antibody titers are affected by age and doses gap time in children from a high endemic area of the western Amazon

Author(s):Show less -

Gomes, Laura Cordeiro ^[1] ; Sanson, Marina Cordeiro Gomes ^[2] ; Brainin, Philip ^[3] ; de Melo, Maria da Conceicao Vieira ^[2] ; de Souza, Rodrigo Medeiros ^[2] ; Mazaro, Janaina ^[4] ; Lima, Karine Oliveira ^[2] ; Resende, Junia Silva ^[2] ; Vieira, Isabelle Victoria Martins ^[2] ; Mesquita, Edinilson da Silva ^[2] ; Matos, Luan Oliveira ^[2] ; Dutra, Isabelle Caroline Silva ^[2] ; Palmisano, Giuseppe ^[5] ; Wrenger, Carsten ^[5] ; Marinho, Claudio Romero Farias ^[5] ; da Silva, Rita do Socorro Uchoa ^[1]

Affiliation

^[1] Univ Fed Acre, Hlth & Sport Sci Ctr, Rio Branco, Acre - Brazil

^[2] Univ Fed Acre, Multidisciplinary Ctr, Cruzeiro Do Sul, Acre - Brazil

^[3] Herlev Gentofte Univ Hosp, Hellerup - Denmark

^[4] Lab Publ Hlth Acre, Cruzeiro Do Sul, Acre - Brazil

^[5] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil

• Document type: Journal article
• Source: PLoS One; v. 16, n. 7 2021.
• Web of Science Citations: 0

Abstract

Background Despite completion of the vaccine schedule for hepatitis B virus (HBV), children may display levels of HBV surface antibodies (anti-HBs) that are considered inadequate for sufficient protection (<10 IU/L). Aims Our aim was to investigate if age and gap time between HBV vaccine doses may negatively affect the levels of anti-HBs in children, and if these relationships are modified by sex. Methods In a high-endemic HBV region of the western Brazilian Amazon we enrolled children who had completed the HBV vaccine schedule. All children underwent analysis of anti-HBs and a clinical examination. Results We included 522 children (mean age 4.3 +/- 0.8 years; 50% male). Median anti-HBs was 28.4 {[}interquartile range (IQR) 5.4 to 128.6] IU/L and 32% had anti-HBs <10 IU/L. The median gap time from last to preceding dose was 2.4 {[}IQR 2.1 to 3.3] months. Levels of anti-HBs decreased with higher age (-42% per year increase {[}95%CI -56% to -24%], p<0.001), but not with longer gap time (+23% per month increase {[}95%CI -16% to +62%], p = 0.249). After adjusting for relevant confounders, gap time became significant (p = 0.032) and age remained a significant predictor of anti-HBs (p<0.001). Conclusion One third of assessed children displayed anti-HBs <10 IU/L. Levels of anti-HBs decreased with higher age and increased with longer gap time between the last two doses. (AU)

• FAPESP's process: 18/20468-0 - Recrudescence of the malaria during pregnancy: effects and mechanisms
• Grantee: Cláudio Romero Farias Marinho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/18257-1 - Multi-user equipment approved in grant 14/06863-3: HPLC system configured for analysis of carbohydrates, amino acidis, peptides and glycoproteins
• Grantee: Giuseppe Palmisano
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 18/15549-1 - Post-translational modifications in Chagas Disease biological processes and diagnostics: novel methodological approaches and biological applications
• Grantee: Giuseppe Palmisano
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 15/26722-8 - Drug discovery against human infectious diseases
• Grantee: Carsten Wrenger
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/06863-3 - Post-translational modifications in cancer and parasite infection diagnosis: methodological approaches and biological implications
• Grantee: Giuseppe Palmisano
• Support Opportunities: Research Grants - Young Investigators Grants