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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Engineering of pH-triggered nanoplatforms based on novel poly(2-methyl-2-oxazoline)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymers with tunable morphologies for biomedical applications

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Author(s):
Cernoch, Peter [1] ; Jager, Alessandro [1] ; Cernochova, Zulfiya [1] ; Sincari, Vladimir [1] ; Albuquerque, Lindomar J. C. [2] ; Konefal, Rafal [1] ; Pavlova, Ewa [1] ; Giacomelli, Fernando C. [2] ; Jager, Eliezer [1]
Total Authors: 9
Affiliation:
[1] Czech Acad Sci, Inst Macromol Chem, Heyrovsky Sq 2, Prague 16206 - Czech Republic
[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Polymer Chemistry; v. 12, n. 19, p. 2868-2880, MAY 21 2021.
Web of Science Citations: 0
Abstract

A two-step synthetic approach via the combination of living cationic ring-opening (CROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization techniques was used to produce novel amphiphilic block copolymers based on the water-soluble poly(2-methyl-2-oxazoline) (PMeOx), which holds protein repelling properties, linked to the hydrophilic-hydrophobic pH-responsive block poly{[}2-(diisopropylamino)ethyl methacrylate] (PDPA). Hydrodynamic flow focusing nanoprecipitation microfluidics (MF) was further employed to manufacture block copolymer self-assemblies. Interestingly, although all the synthesized macromolecules contained higher amounts of the pH-responsive segment, the microfluidic approach allowed the manufacturing of core-shell micelles and polymersomes. The morphology seems to be driven by the overall molecular weight of the block copolymers rather than by the hydrophilic-to-hydrophobic weight ratio. Longer and shorter amphiphilic chains enabled the manufacturing of core-shell assemblies and polymeric vesicles, respectively. The use of PMeOx and PDPA blocks confers serum stability and pH-responsive behavior to the nanoparticles in a pH window which is particularly useful for tumour detection and therapy. The self-assembled nanostructures are non-toxic even at fairly high polymer concentrations. All these features therefore can be useful in the design of pH-triggered nanoplatforms of distinct morphologies towards a variety of biomedical applications, for instance, the loading and delivery of hydrophobic and hydrophilic therapeutics. (AU)

FAPESP's process: 19/06634-8 - Manufacturing and biological evaluations of stimuli-responsive polymersomes towards enhanced efficacy of cancer therapies
Grantee:Fernando Carlos Giacomelli
Support Opportunities: Regular Research Grants
FAPESP's process: 16/23844-8 - Biodegradable and pH-responsive polymersomes for gene and protein delivery
Grantee:Lindomar Jose Calumby Albuquerque
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/11261-0 - Synthesis of PHPMA-b-PDPA, PEO-b-PDPA and RGD-PHPMA-b-PDPA conjugates with further engineering of pH-responsive polymersomes towards the encapsulation and delivery of hydrophilic biomacromolecules
Grantee:Lindomar Jose Calumby Albuquerque
Support Opportunities: Scholarships abroad - Research Internship - Doctorate