Mature T/NK-Cell lymphomas of the oral and maxillofacial region: A multi-institutional collaborative study

Author(s):Show less -

de Arruda, Jose Alcides Almeida ^[1] ; Abrantes, Thamiris de Castro ^[1] ; Cunha, John Lennon Silva ^[2] ; Roza, Ana Luiza Oliveira Correa ^[2] ; Agostini, Michelle ^[3] ; Abrahao, Aline Correa ^[3] ; Canedo, Nathalie Henriques Silva ^[4] ; Ramos, Denize D'Azambuja ^[4] ; Milito, Cristiane Bedran ^[4] ; Pontes, Flavia Sirotheau Correa ^[5] ; Pontes, Helder Antonio Rebelo ^[5] ; Barra, Marinez Bizarro ^[6] ; Zanella, Virgilio Gonzales ^[7] ; Martins, Marco Antonio Trevizani ^{[8, 9]} ; Martins, Manoela Domingues ^{[8, 9]} ; Israel, Monica Simoes ^{[10, 11]} ; Freire, Nathalia de Almeida ^[11] ; Barreto, Maria Eduarda Zeraik ^[11] ; Sanchez-Romero, Celeste ^[2] ; Carlos, Roman ^[12] ; Abreu, Lucas Guimaraes ^[13] ; Vargas, Pablo Agustin ^[2] ; de Almeida, Oslei Paes ^[2] ; Fonseca, Felipe Paiva ^[1] ; Romanach, Mario Jose ^[3] ; Mesquita, Ricardo Alves ^[1] ; de Andrade, Bruno Augusto Benevenuto ^[3]

Affiliation:Show less -

^[1] Univ Fed Minas Gerais, Sch Dent, Dept Oral Surg & Pathol, Belo Horizonte, MG - Brazil

^[2] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba - Brazil

^[3] Univ Fed Rio de Janeiro, Sch Dent, Dept Oral Diag & Pathol, BR-21941902 Rio De Janeiro, RJ - Brazil

^[4] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Sch Med, Dept Pathol, Rio De Janeiro - Brazil

^[5] Fed Univ Para, Hosp Univ Joao Barros Barreto, Serv Oral Pathol, Belem, Para - Brazil

^[6] Santa Rita Hosp, Serv Pathol, Santa Casa Misericordia Porto Alegre, Porto Alegre, RS - Brazil

^[7] Santa Rita Hosp, Santa Casa Misericordia Porto Alegre, Dept Head & Neck Surg, Porto Alegre, RS - Brazil

^[8] Univ Fed Rio Grande do Sul, Sch Dent, Dept Oral Pathol, Porto Alegre, RS - Brazil

^[9] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Oral Med, Porto Alegre, RS - Brazil

^[10] Univ Estado Rio de Janeiro, Sch Dent, Dept Diag & Therapeut, Rio De Janeiro - Brazil

^[11] Fac Sao Leopoldo Mand, Postgrad Program Oral Med, Rio De Janeiro - Brazil

^[12] Hosp Herrera Llerandi, Ctr Clin Cabeza & Cuello, Pathol Sect, Guatemala City - Guatemala

^[13] Univ Fed Minas Gerais, Sch Dent, Dept Childrens & Adolescents Oral Hlth, Belo Horizonte, MG - Brazil

• Document type: Journal article
• Source: JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 50, n. 6, p. 548-557, JUL 2021.
• Web of Science Citations: 0

Abstract

Background The diagnosis of oral and maxillofacial mature T/NK-cell neoplasms is challenging because of their rarity, morphological heterogeneity and complex immunophenotype with scarce available data describing their clinical and microscopic aspects. Therefore, in this study, we investigated a series of mature T/NK-cell neoplasms affecting this anatomical region and provided an updated literature review. Methods Cases diagnosed as mature T/NK-cell lymphomas affecting the oral and maxillofacial region were retrospectively retrieved from six pathology files and their diagnoses were confirmed using haematoxylin and eosin-stained slides, immunohistochemical reactions and in situ hybridization for Epstein-Barr virus (EBV) detection. Patients' clinical data were collected from their pathology forms. Results A total of 22 cases were included in this study. Eleven (50%) consisted of extranodal NK/T-cell lymphomas, nasal type; eight (36.4%) were peripheral T-cell lymphomas, NOS; two (9.1%) were adult T-cell leukaemia/lymphomas, and one (4.5%) was an ALK-positive anaplastic large cell lymphoma. Overall, males predominated, with a mean age of 55.7 years. The palate was the most affected site (50%), and tumours usually presented as destructive and painful ulcers. EBV was present in all cases of extranodal NK/T-cell lymphoma nasal type but was absent in the other subtypes. Conclusion Among mature T/NK-cell lymphomas of the oral and maxillofacial region, extranodal NK/T-cell lymphoma, nasal type and peripheral T-cell lymphoma, NOS predominated. Older men were the most affected patients, and this heterogeneous group of neoplasms has a very aggressive clinical behaviour. (AU)

• FAPESP's process: 17/14880-3 - Clinicopathological and immunohistochemical analysis of follicular lymphoid hyperplasias and lymphomas of the oral cavity
• Grantee: Oslei Paes de Almeida
• Support Opportunities: Regular Research Grants