Microorganisms as bioabatement agents in biomass to bioproducts applications

Author(s)

Sodre, Victoria ^{[1, 2]} ; Vilela, Nathalia ^{[1, 2]} ; Tramontina, Robson ^{[1, 3, 4]} ; Squina, Fabio Marcio ^[1]

Affiliation

^[1] Univ Sorocaba UNISO, Programa Proc Tecnol & Ambientais, Sorocaba, SP - Brazil

^[2] Univ Estadual Campinas, Inst Biol IB, Dept Bioquim & Biol Tecidual DBBT, UNICAMP, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Fac Engn Alimentos FEA, UNICAMP, Campinas, SP - Brazil

^[4] Univ Estadual Campinas, Inst Biol IB, Programa Posgrad Biociencias & Tecnol Prod Bioat, UNICAMP, Campinas, SP - Brazil

• Document type: Journal article
• Source: BIOMASS & BIOENERGY; v. 151, AUG 2021.
• Web of Science Citations: 0

Abstract

The biorefinery concept for production of biofuels and chemicals, based on lignocellulosic biomass, represents an attractive and sustainable alternative to fossil fuel-based refineries. The inherent recalcitrance of lignocellulosic biomass requires a physical-chemical pretreatment prior to the biocatalytic conversion of monomeric constituents of plant cell walls into bioproducts. However, the pretreatment step often generates fermentation inhibitors, such as furfural, 5-hydroxymethylfurfural, aliphatic acids, and phenolic acids and aldehydes. Thus, a detoxification step prior, or simultaneous to microbial fermentation, is of prime importance to improve product yields. Among detoxification strategies, biological detoxification, also known as bioabatement, arises as an ecofriendlier, milder, and cheaper alternative to physical-chemical detoxification methods. In the present review, the state-of-the-art and recent advances in the field of microbial detoxification of lignocellulosic hydrolysates are thoroughly presented. After introducing the general aspects of the theme, including the generation of inhibitory compounds from lignocellulosic biomass pretreatment and their effects on enzymatic hydrolysis and cell physiology, in-depth analyses of biological detoxification strategies reported in the literature are presented for the following microbial groups: filamentous fungi, non-Saccharomyces yeasts, bacteria, and Saccharomyces cerevisiae. Furthermore, the advantages and disadvantages of microbial detoxification are discussed, and the main challenges currently faced by researchers in the field are addressed. (AU)

• FAPESP's process: 18/18101-1 - Development of the CRISPR/Cas9 system in Rhodococcus jostii RHA1 for production of high-value chemicals from lignin streams
• Grantee: Victoria Ramos Sodré de Castro
• Support type: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 15/50590-4 - Lignin valorization in cellulosic ethanol plants: biocatalytic conversion via ferulic acid to high value chemicals
• Grantee: Fábio Márcio Squina
• Support type: Program for Research on Bioenergy (BIOEN) - Thematic Grants
• FAPESP's process: 16/07926-4 - Novel integrative strategies through the aldoketo reductase from the termite Coptotermes gestroi for detoxification, saccharification and fermentation of lignocellulose aiming bioethanol production
• Grantee: Robson Tramontina
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/08166-6 - Genetic engineering of yeast for conversion lignocellulosic material to ferulic acid
• Grantee: Nathália Vilela
• Support type: Scholarships in Brazil - Doctorate