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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Advances and trends in biotechnological production of natural astaxanthin by Phaffia rhodozyma yeast

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Mussagy, Cassamo U. [1, 2] ; Pereira, Jorge F. B. [3] ; Dufosse, Laurent [4] ; Raghavan, Vijaya [5] ; Santos-Ebinuma, Valeria C. [2] ; Pessoa Jr, Adalberto
Total Authors: 6
[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Pharmaceut Biochem Technol, Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Engn Bioproc & Biotechnol, Sao Paulo - Brazil
[3] Univ Coimbra, Dept Chem Engn, CIEPQPF, Rua Silvio Lima, Coimbra - Portugal
[4] Univ La Reunion, Lab Chim & Biotechnol Produits Nat, Chem & Biotechnol Nat Prod CHEMBIOPRO, ESIROI Agroalimentaire, St Denis, Reunion - France
[5] McGill Univ, Fac Agr & Environm Sci, Dept Bioresource EnginCeering, Montreal, PQ - Canada
Total Affiliations: 5
Document type: Review article
Web of Science Citations: 0

Astaxanthin (AXT) is a natural xanthophyll with strong antioxidant, anticancer and antimicrobial activities, widely used in the food, feed, pharmaceutical and nutraceutical industries. So far, 95% of the AXT global market is produced by chemical synthesis, but growing customer preferences for natural products are currently changing the market for natural AXT, highlighting the production from microbially-based sources such as the yeast Phaffia rhodozyma. The AXT production by P. rhodozyma has been studied for a long time at a laboratory scale, but its use in industrial-scale processes is still very scarce. The optimization of growing conditions as well as an effective integration of upstream-downstream operations into P. rhodozyma-based AXT processes has not yet been fully achieved. With this critical review, we scrutinized the main approaches for producing AXT using P. rhodozyma strains, highlighting the impact of using conventional and non-conventional procedures for the extraction of AXT from yeast cells. In addition, we also pinpointed research directions, for example, the use of low-cost residues to improve the economic and environmental sustainability of the bioprocess, the use of environmentally/friendly and low-energetic integrative operations for the extraction and purification of AXT, as well as the need of further human clinical trials using yeast-based AXT. (AU)

FAPESP's process: 17/50303-0 - Sustainable citrus waste biorefining as a source of value added bioproducts
Grantee:Valéria de Carvalho Santos Ebinuma
Support type: Regular Research Grants
FAPESP's process: 15/50058-0 - Characterization and modelling of aqueous two-phase systems (ATPS) composed of ionic liquids (ILs) and polymers: a boost towards develiping sustainable biopharmaceutical separion
Grantee:Jorge Pereira
Support type: Regular Research Grants
FAPESP's process: 14/19793-3 - Optimization and scale-up of novel Ionic-Liquid-based purification processes for recombinant green fluorescent protein produced by Escherichia coli "GFPurIL"
Grantee:Sandro Roberto Valentini
Support type: Regular Research Grants
FAPESP's process: 14/16424-7 - Optimization and scale-up of liquid-liquid extraction process with ionic liquids (ILs) as a sustainable tool for the separation of the anti-leukemia biopharmaceutical L-asparaginase (ASPase)
Grantee:Jorge Pereira
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 18/06908-8 - Development of sustainable nanomaterials for the purification of antileukemic drugs
Grantee:Valéria de Carvalho Santos Ebinuma
Support type: Regular Research Grants
FAPESP's process: 20/08655-0 - Development of a sustainable and biocompatible technology for Astaxanthin recovery and purification: a powerful antioxidant with economic value
Grantee:Cassamo Ussemane Mussagy
Support type: Scholarships in Brazil - Post-Doctorate