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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Purple grumixama anthocyanins (Eugenia brasiliensis Lam.) attenuate obesity and insulin resistance in high-fat diet mice

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Author(s):
Teixeira, Luciane de L. [1, 2] ; Pilon, Genevieve [3, 4] ; Coutinho, Camille Perella [1, 2] ; Dudonne, Stephanie [3] ; Dube, Pascal [3] ; Houde, Vanessa [4] ; Desjardins, Yves [3] ; Lajolo, Franco M. [1, 2] ; Marette, Andre [3, 4] ; Hassimotto, Neuza M. A. [1, 2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Dept Food Sci & Expt Nutr, Sch Pharmaceut Sci, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Food Res Ctr FoRC CEPID, Sch Pharmaceut Sci, Sao Paulo, SP - Brazil
[3] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ - Canada
[4] Cardiol Axis Quebec Heart & Lung Inst, Dept Med, Fac Med, Quebec City, PQ - Canada
Total Affiliations: 4
Document type: Journal article
Source: FOOD & FUNCTION; v. 12, n. 8, p. 3680-3691, APR 21 2021.
Web of Science Citations: 1
Abstract

Some polyphenols have been reported to modulate the expression of several genes related to lipid metabolism and insulin signaling, ameliorating metabolic disorders. We investigated the potential for the polyphenols of two varieties of grumixama, the purple fruit rich in anthocyanins and the yellow fruit, both also rich in ellagitannins, to attenuate obesity-associated metabolic disorders. Mice were fed a high fat and high sucrose diet, supplemented daily with yellow and purple extracts (200 mg per kg of body weight) for eight weeks. Purple grumixama supplementation was found to decrease body weight gain, improve insulin sensitivity and glucose-induced hyperinsulinemia, and reduce hepatic triglyceride accumulation. A decrease in intrahepatic lipids in mice treated with the purple grumixama extract was associated with lipid metabolism modulation by the PPAR signaling pathway. LPL, ApoE, and LDLr were found to be down-regulated, while Acox1 and ApoB were found to be upregulated. Some of these genes were also modulated by the yellow extract. In addition, both extracts decreased oGTT and plasma LPS. The results were associated with the presence of phenolic acids and urolithins. In conclusion, most likely the anthocyanins from the purple grumixama phenolic extract is responsible for reducing obesity and insulin resistance. (AU)

FAPESP's process: 13/07914-8 - FoRC - Food Research Center
Grantee:Bernadette Dora Gombossy de Melo Franco
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC