valuation of hematological, biochemical and oxidative stress profile in calves under propofol anesthesi

Author(s)

Arcanjo Lima, Pedro Paulo ^[1] ; Narciso, Luis Gustavo ^[2] ; Alcindo, Jefferson Filgueira ^[1] ; Deschk, Mauricio ^[1] ; Ciarlini, Paulo Cesar ^[2] ; dos Santos, Paulo Sergio Patto ^[2] ; Martins de Almeida, Breno Fernando ^{[3, 2]}

Affiliation

^[1] Fed Univ Juiz de Fora UFJF, Fac Vet Med, Juiz De Fora, MG - Brazil

^[2] Sao Paulo State Univ, Fac Vet Med Aracatuba, FMVA UNESP, Aracatuba, SP - Brazil

^[3] Univ Ctr Integrated Fac Ourinhos Unifio, Dept Vet Med, Rodovia BR 153, Km 338, BR-19909100 Ourinhos, SP - Brazil

• Document type: Journal article
• Source: VETERINARY RESEARCH COMMUNICATIONS; v. 46, n. 1 SEP 2021.
• Web of Science Citations: 0

Abstract

Propofol is a widely used drug in veterinary medicine to induce anesthesia; as well as the chosen compound for protocols of intravenous anesthesia. The present study aimed to describe the hematological, biochemical and oxidative stress alterations in calves kept under anesthesia by propofol in different dosages. In order to achieve this, eight Holstein calves were induced using propofol in a 5 mg/kg dosage and maintained under continuous propofol infusion for 60 min, having being administered 0.6 mg/kg/h or 0.8 mg/kg/h in crossover design with seven days interval. Blood samples were collected immediately before the anesthesia induction (baseline), and 30 min, 1, 2, 3, 4 and 5 h after the procedure started. Statistically relevant propofol influence was observed both in blood and biochemical parameters, with differences between dosages according to the time of infusion. The drug action over oxidative stress was also observed, causing a raise of the total antioxidant capacity (TAC) with an uric acid increase. Additionally, the increase of triglycerides, induced by the anesthesia maintenance with propofol, caused lipemia in the samples, which was capable of interfering directly in the measurements made by refractometry and spectrophotometry. It was concluded that, in spite of propofol induced alterations in blood and biochemical parameters, such alterations are subtle. In addition to that, the drug presented an antioxidative effect, which reinstates the safety of anesthesia maintenance with propofol in calves. (AU)

• FAPESP's process: 10/11948-7 - BISPECTRAL INDEX, HEMODYNAMIC AND RESPIRATORY EFFECTS OF CONTINUOUS RATE INFUSION OF PROPOFOL IN CALVES.
• Grantee: Mauricio Deschk
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 10/19568-9 - Bispectral index, hemodinamic and respiratory effects of continuous infusion in differents rates of propofol in calves breathing spontaneously
• Grantee: Paulo Sergio Patto dos Santos
• Support Opportunities: Regular Research Grants