Long-term stability of the cortical volumetric profile and the functional human connectome throughout childhood and adolescence

Author(s):Show less -

Sato, Joao Ricardo ^{[1, 2, 3]} ; Biazoli, Claudinei Eduardo ^{[4, 3]} ; Zugman, Andre ^{[1, 2]} ; Pan, Pedro Mario ^{[1, 2]} ; Arantes Bueno, Ana Paula ^[3] ; Moura, Luciana Monteiro ^{[1, 2, 3]} ; Gadelha, Ary ^{[1, 2]} ; Picon, Felipe Almeida ^{[2, 5, 6]} ; Amaro Jr, Edson ; Salum, Giovanni Abrahao ^{[5, 7, 6]} ; Constantino Miguel, Euripedes ^{[8, 7]} ; Rohde, Luis Augusto ^{[5, 7, 6]} ; Bressan, Rodrigo Affonseca ^{[1, 7]} ; Jackowski, Andrea Parolin ^{[1, 7]}

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil

^[2] Natl Inst Dev Psychiat Children & Adolescents CNP, Sao Paulo - Brazil

^[3] Univ Fed ABC, Ctr Math Comp & Cognit, Av Estados, 5001 Bairro Bangu, BR-09210580 Santo Andre, SP - Brazil

^[4] Queen Mary Univ London, Dept Biol & Expt Psychol, London - England

^[5] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dev Psychiat Program, Porto Alegre, RS - Brazil

^[6] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, ADHD Outpatient Program, Porto Alegre, RS - Brazil

^[7] Amaro Jr, Jr., Edson, Natl Inst Dev Psychiat Children & Adolescents CNP, Sao Paulo - Brazil

^[8] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo - Brazil

• Document type: Journal article
• Source: European Journal of Neuroscience; v. 54, n. 6 SEP 2021.
• Web of Science Citations: 0

Abstract

There is compelling evidence showing that between-subject variability in several functional and structural brain features is sufficient for unique identification in adults. However, individuation of brain functional connectomes depends on the stabilization of neurodevelopmental processes during childhood and adolescence. Here, we aimed to (1) evaluate the intra-subject functional connectome stability over time for the whole brain and for large scale functional networks and (2) determine the long-term identification accuracy or `fingerprinting' for the cortical volumetric profile and the functional connectome. For these purposes, we analysed a longitudinal cohort of 239 children and adolescents scanned in two sessions with an interval of approximately 3 years (age range 6-15 years at baseline and 9-18 years at follow-up). Corroborating previous results using short between-scan intervals in children and adolescents, we observed a moderate identification accuracy (38%) for the whole functional profile. In contrast, identification accuracy using cortical volumetric profile was 95%. Among the large-scale networks, the default-mode (26.8%), the frontoparietal (23.4%) and the dorsal-attention (27.6%) networks were the most discriminative. Our results provide further evidence for a protracted development of specific individual structural and functional connectivity profiles. (AU)

• FAPESP's process: 18/21934-5 - Network statistics: theory, methods, and applications
• Grantee: André Fujita
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 16/19376-9 - Structural and functional Papez circuit integrity and its relations to symptomology in Amyotrophic Lateral Sclerosis
• Grantee: Ana Paula Arantes de Andrade Bueno
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/08531-5 - High risk cohort study for psychiatric disorders in childhood: 3-year follow-up neuroimaging study
• Grantee: Andrea Parolin Jackowski
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/50917-0 - INCT 2014: developmental psychiatry for children and adolescents
• Grantee: Eurípedes Constantino Miguel Filho
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/04654-9 - Time series, wavelets and high dimensional data
• Grantee: Pedro Alberto Morettin
• Support Opportunities: Research Projects - Thematic Grants